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Gharbi N, Burghardt S, Brettreich M, et al. Chromatographic separation and identification of a water-soluble dendritic methano[60]fullerene octadecaacid. Anal Chem. 2003;75(16):4217-22doi: 10.1021/ac026419k.
Gharbi, N., Burghardt, S., Brettreich, M., Herrenknecht, C., Tamisier-Karolak, S., Bensasson, R. V., Szwarc, H., Hirsch, A., Wilson, S. R., & Moussa, F. (2003). Chromatographic separation and identification of a water-soluble dendritic methano[60]fullerene octadecaacid. Analytical chemistry, 75(16), 4217-22. https://doi.org/10.1021/ac026419k
Gharbi, Najla, et al. "Chromatographic separation and identification of a water-soluble dendritic methano[60]fullerene octadecaacid." Analytical chemistry vol. 75,16 (2003): 4217-22. doi: https://doi.org/10.1021/ac026419k
Gharbi N, Burghardt S, Brettreich M, Herrenknecht C, Tamisier-Karolak S, Bensasson RV, Szwarc H, Hirsch A, Wilson SR, Moussa F. Chromatographic separation and identification of a water-soluble dendritic methano[60]fullerene octadecaacid. Anal Chem. 2003 Aug 15;75(16):4217-22. doi: 10.1021/ac026419k. PMID: 14632138.
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Anal Chem. 2003 Aug 15;75(16):4217-22. doi: 10.1021/ac026419k.

Chromatographic separation and identification of a water-soluble dendritic methano[60]fullerene octadecaacid.

Analytical chemistry

Najla Gharbi, Stephan Burghardt, Michael Brettreich, Christine Herrenknecht, Sara Tamisier-Karolak, René Victor Bensasson, Henri Szwarc, Andreas Hirsch, Stephen R Wilson, Fathi Moussa

Affiliations

  1. Service de Chimie Analytique, Faculté de Pharmacie, Université Paris XI, Rue J-B Clément, 92 296 Châtenay-Malbry, France.

PMID: 14632138 DOI: 10.1021/ac026419k

Abstract

The chromatographic separation of a highly water-soluble dendritic monoadduct methano[60]fullerene octadecaacid (dendrofullerene) with octadecylsilica bonded phases has been studied. It has been found that the RP-HPLC behavior of this dendrofullerene obeys the general rules of stationary-phase and mobile-phase selection for controlling the separation of usually acidic compounds. An RP-HPLC-ESI-MS analysis confirms the identity of the dendrofullerene and allows characterization of the molecular weights of the main impurities contained in the sample. The described methods can control the synthesis and efficiently purify this fullerene derivative, which has been previously shown to be active against mutant infectious clones of HIV-1, which are resistant to AZT and 3TC, drugs that are widely used in AIDS therapy.

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