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Beyers AD, Spruyt LL, Williams AF. Multimolecular associations of the T-cell antigen receptor. Trends Cell Biol. 1992;2(9):253-5doi: 10.1016/0962-8924(92)90190-x.
Beyers, A. D., Spruyt, L. L., & Williams, A. F. (1992). Multimolecular associations of the T-cell antigen receptor. Trends in cell biology, 2(9), 253-5. https://doi.org/10.1016/0962-8924(92)90190-x
Beyers, A D, et al. "Multimolecular associations of the T-cell antigen receptor." Trends in cell biology vol. 2,9 (1992): 253-5. doi: https://doi.org/10.1016/0962-8924(92)90190-x
Beyers AD, Spruyt LL, Williams AF. Multimolecular associations of the T-cell antigen receptor. Trends Cell Biol. 1992 Sep;2(9):253-5. doi: 10.1016/0962-8924(92)90190-x. PMID: 14731516.
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Trends Cell Biol. 1992 Sep;2(9):253-5. doi: 10.1016/0962-8924(92)90190-x.

Multimolecular associations of the T-cell antigen receptor.

Trends in cell biology

A D Beyers, L L Spruyt, A F Williams

Affiliations

  1. MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, Oxford, UK OX1 3RE.

PMID: 14731516 DOI: 10.1016/0962-8924(92)90190-x

Abstract

T cells are activated when the T-cell receptor for antigen (TCR) interacts with an antigenic peptide bound to a major histocompatibility complex (MHC) molecule on the surface of another cell. It is often assumed that T-cell activation is induced by the crosslinking of TCRs. In this article, Albertus Beyers, Louise Spruyt and Alan Williams argue that this mechanism is not generally applicable. They hypothesize that the key event in T-cell activation is the formation of multimolecular complexes consisting of the TCR and several other polypeptides, including CD4 or CD8, CD2, CD5 and the associated tyrosine kinases p59(fyn) and p56(lck).

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