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Arthritis Res Ther. 2004;6(1):1-5. doi: 10.1186/ar1027. Epub 2003 Nov 25.

Citrullination, a possible functional link between susceptibility genes and rheumatoid arthritis.

Arthritis research & therapy

Erik R Vossenaar, Albert JW Zendman, Walther J Van Venrooij

Affiliations

  1. Department of Biochemistry, University of Nijmegen, The Netherlands. [email protected]

PMID: 14979924 PMCID: PMC400418 DOI: 10.1186/ar1027

Abstract

Antibodies directed to citrullinated proteins (anti-cyclic citrullinated peptide) are highly specific for rheumatoid arthritis (RA). Recent data suggest that the antibodies may be involved in the disease process of RA and that several RA-associated genetic factors might be functionally linked to RA via modulation of the production of anti-cyclic citrullinated peptide antibodies or citrullinated antigens.

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