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Isaksson E, Wang H, Sahlin L, et al. Expression of estrogen receptors (alpha, beta) and insulin-like growth factor-I in breast tissue from surgically postmenopausal cynomolgus macaques after long-term treatment with HRT and tamoxifen. Breast. 2002;11(4):295-300doi: 10.1054/brst.2002.0422.
Isaksson, E., Wang, H., Sahlin, L., von Schoultz, B., Masironi, B., von Schoultz, E., & Cline, J. M. (2002). Expression of estrogen receptors (alpha, beta) and insulin-like growth factor-I in breast tissue from surgically postmenopausal cynomolgus macaques after long-term treatment with HRT and tamoxifen. Breast (Edinburgh, Scotland), 11(4), 295-300. https://doi.org/10.1054/brst.2002.0422
Isaksson, E, et al. "Expression of estrogen receptors (alpha, beta) and insulin-like growth factor-I in breast tissue from surgically postmenopausal cynomolgus macaques after long-term treatment with HRT and tamoxifen." Breast (Edinburgh, Scotland) vol. 11,4 (2002): 295-300. doi: https://doi.org/10.1054/brst.2002.0422
Isaksson E, Wang H, Sahlin L, von Schoultz B, Masironi B, von Schoultz E, Cline JM. Expression of estrogen receptors (alpha, beta) and insulin-like growth factor-I in breast tissue from surgically postmenopausal cynomolgus macaques after long-term treatment with HRT and tamoxifen. Breast. 2002 Aug;11(4):295-300. doi: 10.1054/brst.2002.0422. PMID: 14965685.
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Breast. 2002 Aug;11(4):295-300. doi: 10.1054/brst.2002.0422.

Expression of estrogen receptors (alpha, beta) and insulin-like growth factor-I in breast tissue from surgically postmenopausal cynomolgus macaques after long-term treatment with HRT and tamoxifen.

Breast (Edinburgh, Scotland)

E Isaksson, H Wang, L Sahlin, B von Schoultz, B Masironi, E von Schoultz, J M Cline

Affiliations

  1. Department of Oncology, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden. [email protected]

PMID: 14965685 DOI: 10.1054/brst.2002.0422

Abstract

The novel estrogen receptor ERbeta could be a key factor for proliferation and breast cancer risk. In a primate model for long-term HRT, surgically postmenopausal cynomolgus macaques were treated for 35 months with conjugated equine estrogens (CEE), medroxyprogesterone acetate (MPA), CEE+MPA and tamoxifen (n=5 in all groups). The immunohistochemical expression of ERalpha, ERbeta and IGF-I in breast tissue was quantified by image analysis. Overall the levels of ERbeta were higher than for ERalpha. In untreated animals, the median area of positive cells was 58% and 21%. The lowest levels for ERbeta were seen during treatment with CEE/MPA (3%) and in this group the expression of ERbeta was lower than for ERalpha. Tamoxifen had effects similar to estrogen. ERbeta may have a role to modulate the proliferative response following activation of ERalpha. The results suggest that hormonal treatments have a different influence on the balance ERbeta/ERalpha in breast tissue.

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