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Pettitt JM, van Driel IR, Toh BH, et al. From coiled tubules to a secretory canaliculus: a new model for membrane transformation and acid secretion by gastric parietal cells. Trends Cell Biol. 1996;6(2):49-53doi: 10.1016/0962-8924(96)81010-5.
Pettitt, J. M., van Driel, I. R., Toh, B. H., & Gleeson, P. A. (1996). From coiled tubules to a secretory canaliculus: a new model for membrane transformation and acid secretion by gastric parietal cells. Trends in cell biology, 6(2), 49-53. https://doi.org/10.1016/0962-8924(96)81010-5
Pettitt, J M, et al. "From coiled tubules to a secretory canaliculus: a new model for membrane transformation and acid secretion by gastric parietal cells." Trends in cell biology vol. 6,2 (1996): 49-53. doi: https://doi.org/10.1016/0962-8924(96)81010-5
Pettitt JM, van Driel IR, Toh BH, Gleeson PA. From coiled tubules to a secretory canaliculus: a new model for membrane transformation and acid secretion by gastric parietal cells. Trends Cell Biol. 1996 Feb;6(2):49-53. doi: 10.1016/0962-8924(96)81010-5. PMID: 15157490.
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Trends Cell Biol. 1996 Feb;6(2):49-53. doi: 10.1016/0962-8924(96)81010-5.

From coiled tubules to a secretory canaliculus: a new model for membrane transformation and acid secretion by gastric parietal cells.

Trends in cell biology

J M Pettitt, I R van Driel, B H Toh, P A Gleeson

Affiliations

  1. Dept of Pathology and Immunology, Monash University Medical School, Commercial Rd, Prahran, VIC 3181, Australia.

PMID: 15157490 DOI: 10.1016/0962-8924(96)81010-5

Abstract

The acid-secreting gastric parietal cell has a unique secretory membrane system. This membrane system exists in an inactive (non-secreting) and an active (secreting) form. The current accepted model to explain the transformation events associated with the conversion of the non-secreting membrane to the secreting membrane, and vice versa, invokes membrane recycling of elongated vesicle structures. However, recent studies employing cryopreparation have shown that the non-secreting membrane in these cells is actually a complex network of helically coiled tubules. Here, we present an alternative model to explain how the membrane in parietal cells is activated to secrete HCl.

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