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Flockhart DA, Nelson HS. Single isomer versus racemate: is there a difference? Clinical comparisons in allergy and gastroenterology. CNS Spectr. 2002;7(4):23-7doi: 10.1017/s109285290002856x.
Flockhart, D. A., & Nelson, H. S. (2002). Single isomer versus racemate: is there a difference? Clinical comparisons in allergy and gastroenterology. CNS spectrums, 7(4), 23-7. https://doi.org/10.1017/s109285290002856x
Flockhart, David A, and Nelson, Harold S. "Single isomer versus racemate: is there a difference? Clinical comparisons in allergy and gastroenterology." CNS spectrums vol. 7,4 (2002): 23-7. doi: https://doi.org/10.1017/s109285290002856x
Flockhart DA, Nelson HS. Single isomer versus racemate: is there a difference? Clinical comparisons in allergy and gastroenterology. CNS Spectr. 2002 Apr;7(4):23-7. doi: 10.1017/s109285290002856x. PMID: 15131489.
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CNS Spectr. 2002 Apr;7(4):23-7. doi: 10.1017/s109285290002856x.

Single isomer versus racemate: is there a difference? Clinical comparisons in allergy and gastroenterology.

CNS spectrums

David A Flockhart, Harold S Nelson

Affiliations

  1. Department of Clinical pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

PMID: 15131489 DOI: 10.1017/s109285290002856x

Abstract

Many commonly prescribed drugs exist as a mixture of two distinct chiral isomer forms (enantiomers), each with its own unique chemistry, receptor affinity, and pharmacokinetic profile. Much is unknown concerning the clinical utility of these single enantiomers. This review of the stereoisomers of two commonly used drugs--albuterol for asthma and omeprazole for gastroesophageal reflux disease (GERD) and peptic ulcers--examines the improved efficacy, pharmacokinetics, decreased adverse effects, and fewer drug-drug interactions associated with single enantiomers.

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