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Petronis A, Popendikyte V, Kan P, et al. Major psychosis and chromosome 22: genetics meets epigenetics. CNS Spectr. 2002;7(3):209-14doi: 10.1017/s1092852900017570.
Petronis, A., Popendikyte, V., Kan, P., & Sasaki, T. (2002). Major psychosis and chromosome 22: genetics meets epigenetics. CNS spectrums, 7(3), 209-14. https://doi.org/10.1017/s1092852900017570
Petronis, Arturas, et al. "Major psychosis and chromosome 22: genetics meets epigenetics." CNS spectrums vol. 7,3 (2002): 209-14. doi: https://doi.org/10.1017/s1092852900017570
Petronis A, Popendikyte V, Kan P, Sasaki T. Major psychosis and chromosome 22: genetics meets epigenetics. CNS Spectr. 2002 Mar;7(3):209-14. doi: 10.1017/s1092852900017570. PMID: 15211284.
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CNS Spectr. 2002 Mar;7(3):209-14. doi: 10.1017/s1092852900017570.

Major psychosis and chromosome 22: genetics meets epigenetics.

CNS spectrums

Arturas Petronis, Violeta Popendikyte, Peixiang Kan, Tsukasa Sasaki

Affiliations

  1. Department of Psychiatry, University of Toronto, Toronto, Canada. [email protected]

PMID: 15211284 DOI: 10.1017/s1092852900017570

Abstract

Elucidation of genetic factors in schizophrenia and bipolar disorder remains a challenging task to psychiatric researchers. As a rule, data from genetic linkage and association studies are quite controversial. In this article, we further explore the possibility that in addition to DNA sequences variation, a putative epigenetic dysregulation of brain genes plays an important role in the etiopathogenesis of major psychosis. We provide an epigenetic interpretation of unclear genetic findings specifically pertaining to chromosome 22 in schizophrenia and bipolar disorder. It is suggested that epigenetic strategies, when applied in conjunction with traditional genetic ones, may significantly expedite the uncovering of the molecular causes of major psychosis.

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