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Masaki E, Yasuda N, Tanifuji Y, et al. Effect of halothane and enflurane on hepatic blood flow and oxygen consumption in dogs. J Anesth. 1989;3(2):118-22doi: 10.1007/s0054090030118.
Masaki, E., Yasuda, N., Tanifuji, Y., Kimura, J., & Kobayashi, K. (1989). Effect of halothane and enflurane on hepatic blood flow and oxygen consumption in dogs. Journal of anesthesia, 3(2), 118-22. https://doi.org/10.1007/s0054090030118
Masaki, E, et al. "Effect of halothane and enflurane on hepatic blood flow and oxygen consumption in dogs." Journal of anesthesia vol. 3,2 (1989): 118-22. doi: https://doi.org/10.1007/s0054090030118
Masaki E, Yasuda N, Tanifuji Y, Kimura J, Kobayashi K. Effect of halothane and enflurane on hepatic blood flow and oxygen consumption in dogs. J Anesth. 1989 Sep 01;3(2):118-22. doi: 10.1007/s0054090030118. PMID: 15236026.
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J Anesth. 1989 Sep 01;3(2):118-22. doi: 10.1007/s0054090030118.

Effect of halothane and enflurane on hepatic blood flow and oxygen consumption in dogs.

Journal of anesthesia

E Masaki, N Yasuda, Y Tanifuji, J Kimura, K Kobayashi

Affiliations

  1. Department of Anesthesiology, Jikei University School of Medicine Tokyo, Japan.

PMID: 15236026 DOI: 10.1007/s0054090030118

Abstract

We investigated the relative effects of 0.5, 1.0, 1.5, 2.0 MAC halothane and enflurane, and concurrent noxious stimulus on hepatic blood flow and oxygen consumption in 14 mongrel dogs randomly divided into groups of seven each. Hepatic arterial and portal venous blood flow (HABF and PVBF, respectively) were measured continuously using ultrasonic transit time flow meter. Mean arterial blood pressure (MAP), cardiac index (CI), hepatic oxygen supply, and hepatic oxygen consumption (HVO2) were measured. Halothane significantly deceased HABF, but not PVBF in a dose dependent manner. Enflurane did not affect HABF and PVBF significantly. MAP and CI decreased in both groups, with halothane producing more marked decreases than enflurane. HVO2 did not change with enflurane, but did with halothane, producing significant differences, with halothane being greater at 1.5, 2.0 MAC. A noxious stimulus only caused minor change in blood flow. The results suggest that liver blood flow and oxygen consumption are affected differently by halothane and enflurane and that halothane has a stronger tendency to cause an imbalance between liver oxygen supply and consumption than dose enflurane.

References

  1. Br J Anaesth. 1980 Nov;52(11):1079-86 - PubMed
  2. Anesth Analg. 1982 Oct;61(10 ):824-7 - PubMed
  3. Br J Anaesth. 1979 Jul;51(7):627-40 - PubMed
  4. Am J Surg. 1967 Sep;114(3):353-8 - PubMed
  5. Anesthesiology. 1987 Mar;66(3):337-43 - PubMed
  6. Am J Physiol. 1969 Apr;216(4):946-52 - PubMed
  7. Am J Physiol. 1977 Oct;233(4):E255-62 - PubMed
  8. Anesthesiology. 1976 Nov;45(5):501-7 - PubMed
  9. Anesthesiology. 1984 Dec;61(6):726-30 - PubMed
  10. Acta Anaesthesiol Scand Suppl. 1982;75:25-31 - PubMed
  11. Br J Anaesth. 1975 Dec;47(12):1253-9 - PubMed
  12. Acta Anaesthesiol Scand. 1975;19(2):146-53 - PubMed
  13. Masui. 1985 May;34(5):619-25 - PubMed
  14. Anesth Analg. 1982 Oct;61(10 ):809-11 - PubMed
  15. Acta Anaesthesiol Scand. 1979 Feb;23(1):13-26 - PubMed
  16. Anesthesiology. 1963 Jan-Feb;24:29-37 - PubMed
  17. Masui. 1982 Sep;31(9):956-61 - PubMed
  18. Anesthesiology. 1985 Oct;63(4):424-39 - PubMed
  19. Masui. 1983 Nov;32(11):1364-76 - PubMed

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