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Okuda M, Muneyuki M, Sogabe T, et al. Effects of various catecholamines on high-energy phosphates of rat liver and brain during hemorrhagic shock measured by 31P-NMR spectroscopy. J Anesth. 1989;3(2):200-9doi: 10.1007/s0054090030200.
Okuda, M., Muneyuki, M., Sogabe, T., & Miura, I. (1989). Effects of various catecholamines on high-energy phosphates of rat liver and brain during hemorrhagic shock measured by 31P-NMR spectroscopy. Journal of anesthesia, 3(2), 200-9. https://doi.org/10.1007/s0054090030200
Okuda, M, et al. "Effects of various catecholamines on high-energy phosphates of rat liver and brain during hemorrhagic shock measured by 31P-NMR spectroscopy." Journal of anesthesia vol. 3,2 (1989): 200-9. doi: https://doi.org/10.1007/s0054090030200
Okuda M, Muneyuki M, Sogabe T, Miura I. Effects of various catecholamines on high-energy phosphates of rat liver and brain during hemorrhagic shock measured by 31P-NMR spectroscopy. J Anesth. 1989 Sep 01;3(2):200-9. doi: 10.1007/s0054090030200. PMID: 15236039.
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J Anesth. 1989 Sep 01;3(2):200-9. doi: 10.1007/s0054090030200.

Effects of various catecholamines on high-energy phosphates of rat liver and brain during hemorrhagic shock measured by 31P-NMR spectroscopy.

Journal of anesthesia

M Okuda, M Muneyuki, T Sogabe, I Miura

Affiliations

  1. Department of Anesthesiology, Mie University, School of Medicine, Tsu, Japan.

PMID: 15236039 DOI: 10.1007/s0054090030200

Abstract

The effects of dopamine, epinephrine and norepinephrine on energy metabolism as well as intracellular pH in rat liver and brain during hemorrhagic shock were examined by in vivo 31P-NMR spectroscopy. The hemorrhagic shock was induced by arterial bleeding to a mean arterial pressure (MAP) of 30-40 mmHg. Upon the induction of hemorrhagic shock, there was a dramatic fall in adenosine triphosphate (ATP) and a rise in inorganic phosphate (Pi) in the liver. The intracellular pH indicated severe acidosis. However, no change in these parameters was observed in the brain during hemorrhagic shock. After infusion of the above catechollamines following 10 min of hemorrhagic shock, MAP increased to 90-100% of its control value. Only dopamine improved hepatic energy metabolism, whereas brain energy metabolism was not affected by any of them. This suggests that dopamine protects liver function during hemorrhagic shock without affecting brain energy metabolism.

References

  1. Neurology. 1972 Sep;22(9):978-87 - PubMed
  2. Annu Rev Physiol. 1979;41:749-69 - PubMed
  3. Am J Physiol. 1962 Jan;202:7-11 - PubMed
  4. J Clin Invest. 1952 Mar;31(3):273-9 - PubMed
  5. Biochemistry. 1981 Sep 15;20(19):5389-94 - PubMed
  6. Am J Physiol. 1983 Dec;245(6):H930-6 - PubMed
  7. J Pharmacol Exp Ther. 1969 Aug;168(2):303-9 - PubMed
  8. Science. 1959 May 1;129(3357):1226-7 - PubMed
  9. Crit Care Med. 1981 Jan;9(1):14-6 - PubMed
  10. Am J Physiol. 1969 Jun;216(6):1380-5 - PubMed
  11. J Clin Invest. 1968 Jul;47(7):1672-84 - PubMed
  12. Acta Neurol Scand. 1974;50(1):11-26 - PubMed
  13. J Physiol. 1967 Nov;193(2):375-9 - PubMed
  14. Acta Physiol Scand. 1973 Mar;87(3):307-19 - PubMed
  15. Arch Neurol. 1974 Sep;31(3):197-9 - PubMed
  16. Acta Physiol Scand. 1973 Oct;89(2):269-77 - PubMed
  17. Biochem Pharmacol. 1975 Mar 15;24(6):651-3 - PubMed
  18. Anesthesiology. 1972 Jul;37(1):32-9 - PubMed
  19. Am J Physiol. 1973 Aug;225(2):432-7 - PubMed
  20. Acta Neurol Scand. 1974;50(1):39-52 - PubMed
  21. Acta Physiol Scand. 1970 Apr;78(4):448-58 - PubMed
  22. Biochim Biophys Acta. 1986 Jan 23;885(1):1-11 - PubMed
  23. Circ Res. 1973 Jul;33(1):98-104 - PubMed
  24. Annu Rev Biochem. 1981;50:69-83 - PubMed
  25. Jpn J Pharmacol. 1974 Jun;24(3):373-81 - PubMed
  26. N Engl J Med. 1976 Oct 7;295(15):814-8 - PubMed
  27. Angiologica. 1973;10(2):65-75 - PubMed
  28. Arch Neurol. 1960 Apr;2:435-8 - PubMed
  29. Am J Physiol. 1962 Jun;202:1175-8 - PubMed
  30. J Biochem. 1982 Apr;91(4):1349-56 - PubMed
  31. Brain Res. 1969 Mar;13(1):68-100 - PubMed
  32. Eur Neurol. 1971-1972;6(1):208-12 - PubMed
  33. J Biochem. 1983 Sep;94(3):729-34 - PubMed
  34. Science. 1971 Aug 13;173(3997):598-606 - PubMed
  35. Am Heart J. 1975 Sep;90(3):340-5 - PubMed
  36. Surg Gynecol Obstet. 1963 Dec;117:753-8 - PubMed
  37. Am J Physiol. 1966 Sep;211(3):712-20 - PubMed

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