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Iwatsuki N, Katoh M, Yasuda A, et al. Effects of intravenously administered human atrial natriuretic peptide on elevated blood pressure during surgery. J Anesth. 1989;3(2):218-22doi: 10.1007/s0054090030218.
Iwatsuki, N., Katoh, M., Yasuda, A., Saitoh, S., & Asano, M. (1989). Effects of intravenously administered human atrial natriuretic peptide on elevated blood pressure during surgery. Journal of anesthesia, 3(2), 218-22. https://doi.org/10.1007/s0054090030218
Iwatsuki, N, et al. "Effects of intravenously administered human atrial natriuretic peptide on elevated blood pressure during surgery." Journal of anesthesia vol. 3,2 (1989): 218-22. doi: https://doi.org/10.1007/s0054090030218
Iwatsuki N, Katoh M, Yasuda A, Saitoh S, Asano M. Effects of intravenously administered human atrial natriuretic peptide on elevated blood pressure during surgery. J Anesth. 1989 Sep 01;3(2):218-22. doi: 10.1007/s0054090030218. PMID: 15236041.
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J Anesth. 1989 Sep 01;3(2):218-22. doi: 10.1007/s0054090030218.

Effects of intravenously administered human atrial natriuretic peptide on elevated blood pressure during surgery.

Journal of anesthesia

N Iwatsuki, M Katoh, A Yasuda, S Saitoh, M Asano

Affiliations

  1. Department of Anesthesiology, Tohoku University School of Medicine, Sendai, Japan.

PMID: 15236041 DOI: 10.1007/s0054090030218

Abstract

The effect of human atrial natriuretic peptide (hANP) on blood pressure (Bp) was evaluated in 11 patients who had elevated systoric Bp of over 150 mmHg during surgery. A bolus injection of 50 microg or 100 microg of hANP decreased Bp with an immediate response by 27.6 +/- 3.1 mmHg (P < 0.001) or 40.7 +/- 4.2 mmHg (P < 0.001), respectively, accompanying with tremendously increased urine output. Heart rate and PaO2 were not altered. Thus, a intravenous bolus injection of hANP is an useful therapeutic tool for the treatment of acutely elevated Bp during anesthesia.

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