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Kishikawa K, Namiki A, Iwasaki H. The cardiovascular effects of naloxone administration after fentanyl anesthesia in hypercapnic patients. J Anesth. 1989;3(1):48-53doi: 10.1007/s0054090030048.
Kishikawa, K., Namiki, A., & Iwasaki, H. (1989). The cardiovascular effects of naloxone administration after fentanyl anesthesia in hypercapnic patients. Journal of anesthesia, 3(1), 48-53. https://doi.org/10.1007/s0054090030048
Kishikawa, Kazuhiro, et al. "The cardiovascular effects of naloxone administration after fentanyl anesthesia in hypercapnic patients." Journal of anesthesia vol. 3,1 (1989): 48-53. doi: https://doi.org/10.1007/s0054090030048
Kishikawa K, Namiki A, Iwasaki H. The cardiovascular effects of naloxone administration after fentanyl anesthesia in hypercapnic patients. J Anesth. 1989 Mar 01;3(1):48-53. doi: 10.1007/s0054090030048. PMID: 15236056.
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J Anesth. 1989 Mar 01;3(1):48-53. doi: 10.1007/s0054090030048.

The cardiovascular effects of naloxone administration after fentanyl anesthesia in hypercapnic patients.

Journal of anesthesia

Kazuhiro Kishikawa, Akiyoshi Namiki, Hiroshi Iwasaki

Affiliations

  1. Department of Anesthesiology, Sapporo Medical College and Hospital, Minami 1, Nishi 16, Chuou-ku, 060, Sapporo, Hokkaido, Japan.

PMID: 15236056 DOI: 10.1007/s0054090030048

Abstract

Hemodynamic changes and plasma catecholamine levels after naloxone administration were studied in seventeen postoperative patients who received nitrous oxide, oxygen, and fentanyl anesthesia combined with epidural block. Group I consisted of ten postoperative hypercapnic (PaCO2 = 55.2 +/- 2.4 torr) and group II seven postoperative normocapnic patients (PaCO2 = 38.4 +/- 2.1 torr), respectively. In group I, naloxone reversal resulted in significant increases in heart rate (13.5%), mean arterial pressure (46.6%), systemic vascular resistance (32.1%), and rate pressure product (68.8%), whereas mean pulmonary artery pressure and pulmonary vascular resistance were significantly decreased. No significant hemodynamic changes after naloxone administration were observed in group II. There were no significant differences in arterial norepinephrine and epinephrine levels either before or after naloxone administration in the both groups. This study indicates that the postoperative hypercapnia elicits the cardiovascular stimulation after fentanyl reversal by naloxone.

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