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García Rodríguez LA, Wallander MA, Johanson S, et al. Renal disease and acid-suppressing drugs. Pharmacoepidemiol Drug Saf. 1997;6(4):247-51doi: 10.1002/(SICI)1099-1557(199707)6:4<247::AID-PDS296>3.0.CO;2-O.
García Rodríguez, L. A., Wallander, M. A., Johanson, S., & Björck, S. (1997). Renal disease and acid-suppressing drugs. Pharmacoepidemiology and drug safety, 6(4), 247-51. https://doi.org/10.1002/(SICI)1099-1557(199707)6:4<247::AID-PDS296>3.0.CO;2-O
García Rodríguez, L A, et al. "Renal disease and acid-suppressing drugs." Pharmacoepidemiology and drug safety vol. 6,4 (1997): 247-51. doi: https://doi.org/10.1002/(SICI)1099-1557(199707)6:4<247::AID-PDS296>3.0.CO;2-O
García Rodríguez LA, Wallander MA, Johanson S, Björck S. Renal disease and acid-suppressing drugs. Pharmacoepidemiol Drug Saf. 1997 Jul;6(4):247-51. doi: 10.1002/(SICI)1099-1557(199707)6:4<247::AID-PDS296>3.0.CO;2-O. PMID: 15073775.
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Pharmacoepidemiol Drug Saf. 1997 Jul;6(4):247-51. doi: 10.1002/(SICI)1099-1557(199707)6:4<247::AID-PDS296>3.0.CO;2-O.

Renal disease and acid-suppressing drugs.

Pharmacoepidemiology and drug safety

L A García Rodríguez, M A Wallander, S Johanson, S Björck

Affiliations

  1. Centro Español de Investigación Farmacoepidemiológica, Universidad Complutense de Madrid, Madrid, Spain.

PMID: 15073775 DOI: 10.1002/(SICI)1099-1557(199707)6:4<247::AID-PDS296>3.0.CO;2-O

Abstract

No comparative epidemiological data can be found in the literature on the renal safety of acid-suppressing drugs. We followed-up a cohort of close to 180,000 persons during periods of treatment and non-treatment with five anti-ulcer drugs to evaluate the risk of idiopathic acute renal failure and/or nephrotic syndrome. After reviewing medical records, five patients were found to be cases. Two presented with acute renal failure and three had nephrotic syndrome. Three cases occurred during periods of non-exposure to anti-ulcer drugs. Two cases occurred during current use of ranitidine: one of acute renal failure and one of nephrotic syndrome. No case was encountered during treatment with cimetidine, famotidine, nizatidine or omeprazole. The incidence of idiopathic renal disease in the general population was 1 per 100,000 person-years. The relative risk associated with use of acid-suppressing drugs was 1.8 (95% CI, 0.3-10.7) compared to non-use. These results do not suggest a major increased risk for acute renal injury and/or nephrotic syndrome associated with use of anti-ulcer drugs.

Copyright 1997 John Wiley & Sons, Ltd.

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