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Dalton JP, Smith AM, Clough KA, et al. Digestion of haemoglobin by schistosomes: 35 years on. Parasitol Today. 1995;11(8):299-303doi: 10.1016/0169-4758(95)80045-x.
Dalton, J. P., Smith, A. M., Clough, K. A., & Brindley, P. J. (1995). Digestion of haemoglobin by schistosomes: 35 years on. Parasitology today (Personal ed.), 11(8), 299-303. https://doi.org/10.1016/0169-4758(95)80045-x
Dalton, J P, et al. "Digestion of haemoglobin by schistosomes: 35 years on." Parasitology today (Personal ed.) vol. 11,8 (1995): 299-303. doi: https://doi.org/10.1016/0169-4758(95)80045-x
Dalton JP, Smith AM, Clough KA, Brindley PJ. Digestion of haemoglobin by schistosomes: 35 years on. Parasitol Today. 1995 Aug;11(8):299-303. doi: 10.1016/0169-4758(95)80045-x. PMID: 15275329.
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Parasitol Today. 1995 Aug;11(8):299-303. doi: 10.1016/0169-4758(95)80045-x.

Digestion of haemoglobin by schistosomes: 35 years on.

Parasitology today (Personal ed.)

J P Dalton, A M Smith, K A Clough, P J Brindley

Affiliations

  1. School of Biological Sciences, Dublin City University, Republic of Ireland. [email protected]

PMID: 15275329 DOI: 10.1016/0169-4758(95)80045-x

Abstract

Adult schistosomes obtain nutrients by digesting haemoglobin, which they obtain from ingested host red blood cells. Here John Dalton, Angela Smith, Karen Clough and Paul Brindley argue that a cathepsin L proteinase recently identified in their laboratory as the predominant cysteine proteinase activity of Schistosoma mansoni may play the leading role in haemoglobin digestion. They discuss the importance of elucidating the roles of both cathepsin B and cathepsin L in the digestion of haemoglobin, since both should be considered important targets to which novel schistosomicidal agents could be directed.

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