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Hoka S, Yoshitake J, Dan K, et al. Intra-operative blood pressure control by prostaglandin E1 in patients with hypertension and ischemic heart disease--a multi-center study. J Anesth. 1993;7(2):173-83doi: 10.1007/s0054030070173.
Hoka, S., Yoshitake, J., Dan, K., Goto, Y., Honda, N., Morioka, T., Muteki, T., Okuda, Y., Shigematsu, A., Takasaki, M., Totoki, T., Yoshimura, N. (1993). Intra-operative blood pressure control by prostaglandin E1 in patients with hypertension and ischemic heart disease--a multi-center study. Journal of anesthesia, 7(2), 173-83. https://doi.org/10.1007/s0054030070173
Hoka, S, et al. "Intra-operative blood pressure control by prostaglandin E1 in patients with hypertension and ischemic heart disease--a multi-center study." Journal of anesthesia vol. 7,2 (1993): 173-83. doi: https://doi.org/10.1007/s0054030070173
Hoka S, Yoshitake J, Dan K, Goto Y, Honda N, Morioka T, Muteki T, Okuda Y, Shigematsu A, Takasaki M, Totoki T, Yoshimura N. Intra-operative blood pressure control by prostaglandin E1 in patients with hypertension and ischemic heart disease--a multi-center study. J Anesth. 1993 Apr;7(2):173-83. doi: 10.1007/s0054030070173. PMID: 15278470.
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J Anesth. 1993 Apr;7(2):173-83. doi: 10.1007/s0054030070173.

Intra-operative blood pressure control by prostaglandin E1 in patients with hypertension and ischemic heart disease--a multi-center study.

Journal of anesthesia

S Hoka, J Yoshitake, K Dan, Y Goto, N Honda, T Morioka, T Muteki, Y Okuda, A Shigematsu, M Takasaki, T Totoki, N Yoshimura,

Affiliations

  1. Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Kyushu University, Fukuoka, 812 Japan.

PMID: 15278470 DOI: 10.1007/s0054030070173

Abstract

The purpose of this multi-center study was to evaluate the efficacy and safety of prostaglandin E1 (PGE1) administration in achieving deliberate hypotension and in treating intraoperative hypertension for patients with a history of hypertension and ischemic heart disease. PGE1 (0.08 microg.kg(-1).min(-1)) decreased systolic blood pressure from 125 +/- 29 to 106 +/- 22 mmHg (mean +/- SD) in the deliberate hypotension group (n = 158) and from 155 +/- 34 to 125 +/- 32 mmHg in the antihypertension group (n = 55). The heart rate significantly increased from 80 +/- 15 to 85 +/- 18 beats.min(-1) in the deliberate hypotension group, but was not significantly altered in the antihypertension group. The time required to obtain the desired level of blood pressure was approximately 20 min in the deliberate hypotension group. When the infusion was stopped, blood pressure returned approximately to the preinfusion level within about 20 min. No rebound hypertension was observed. PGE1 significantly increased the urine flow in patients who had a low urine flow before PGE1 infusion. Thirteen out of 213 patients (5.6%) had side effects such as excessive hypotension (1%), phlebitis (3%), and unexpected tachycardia (1%), which were alleviated gradually after discontinuation of PGE1 infusion. No dysarrhythmia and further ST segment changes in the electrocardiograms were observed. These findings suggest that PGE1 can be safely used to control arterial blood pressure during surgery in patients having preoperative hypertension and ischemic heart disease.

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