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Kashimoto S, Nonaka A, Nakamura T, et al. Cardiac and hepatic metabolism in spontaneously hypertensive rats following acute blood loss. J Anesth. 1992;6(3):284-8doi: 10.1007/s0054020060284.
Kashimoto, S., Nonaka, A., Nakamura, T., Yamaguchi, T., & Kumazawa, T. (1992). Cardiac and hepatic metabolism in spontaneously hypertensive rats following acute blood loss. Journal of anesthesia, 6(3), 284-8. https://doi.org/10.1007/s0054020060284
Kashimoto, S, et al. "Cardiac and hepatic metabolism in spontaneously hypertensive rats following acute blood loss." Journal of anesthesia vol. 6,3 (1992): 284-8. doi: https://doi.org/10.1007/s0054020060284
Kashimoto S, Nonaka A, Nakamura T, Yamaguchi T, Kumazawa T. Cardiac and hepatic metabolism in spontaneously hypertensive rats following acute blood loss. J Anesth. 1992 Jul;6(3):284-8. doi: 10.1007/s0054020060284. PMID: 15278538.
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J Anesth. 1992 Jul;6(3):284-8. doi: 10.1007/s0054020060284.

Cardiac and hepatic metabolism in spontaneously hypertensive rats following acute blood loss.

Journal of anesthesia

S Kashimoto, A Nonaka, T Nakamura, T Yamaguchi, T Kumazawa

Affiliations

  1. Department of Anesthesiology, Kohfu City Hospital, Kohfu, Japan.

PMID: 15278538 DOI: 10.1007/s0054020060284

Abstract

Seven spontaneously hypertensive rats (SHRs) and eight Wistar-St rats were used to assess the influence of hemorrhage on myocardial and hepatic energy metabolism. They received 2% halothane and pancuronium, 0.3 mg.kg(-1), during preparation. After discontinuation of halothane, blood (2 ml.100 g body weight(-1)) was gradually withdrawn over a 5 min period from a femoral artery. Thirty min after induction of hemorrhage, the heart and liver were removed and myocardial and hepatic metabolites (ATP, lactate, pyruvate and glycogen) were measured by the enzymatic methods. Acidosis and decreased hematocrit were noted in the both groups after hemorrhage. Mean arterial pressure (MAP) in SHR was significantly higher than that in Wistar rat before hemorrhage. However, there were no significant differences in MAP and heart rate between the two groups after hemorrhage. Although there were no significant differences in cardiac metabolites, a significant decrease of hepatic ATP and an increase of hepatic lactate/pyruvate ratio were found in SHR when compared with Wistar rat. These results suggest that human hypertensive disease may run a high risk in connection with acute hemorrhage.

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