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Sakaguchi Y, Inaba S, Umeki Y, et al. Retrospective study of post-anesthetic mild liver disorder associated with inhalation anesthetics, halothane and enflurane. J Anesth. 1992;6(2):183-91doi: 10.1007/s0054020060183.
Sakaguchi, Y., Inaba, S., Umeki, Y., Takahashi, S., Yoshitake, J., Hayashi, Y., Akazawa, K., & Nose, Y. (1992). Retrospective study of post-anesthetic mild liver disorder associated with inhalation anesthetics, halothane and enflurane. Journal of anesthesia, 6(2), 183-91. https://doi.org/10.1007/s0054020060183
Sakaguchi, Y, et al. "Retrospective study of post-anesthetic mild liver disorder associated with inhalation anesthetics, halothane and enflurane." Journal of anesthesia vol. 6,2 (1992): 183-91. doi: https://doi.org/10.1007/s0054020060183
Sakaguchi Y, Inaba S, Umeki Y, Takahashi S, Yoshitake J, Hayashi Y, Akazawa K, Nose Y. Retrospective study of post-anesthetic mild liver disorder associated with inhalation anesthetics, halothane and enflurane. J Anesth. 1992 Apr;6(2):183-91. doi: 10.1007/s0054020060183. PMID: 15278564.
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J Anesth. 1992 Apr;6(2):183-91. doi: 10.1007/s0054020060183.

Retrospective study of post-anesthetic mild liver disorder associated with inhalation anesthetics, halothane and enflurane.

Journal of anesthesia

Y Sakaguchi, S Inaba, Y Umeki, S Takahashi, J Yoshitake, Y Hayashi, K Akazawa, Y Nose

Affiliations

  1. Department of Anesthesiology and Critical care Medicine, Kyushu University, Fukuoka, Japan.

PMID: 15278564 DOI: 10.1007/s0054020060183

Abstract

The incidence of post-anesthetic mild liver disorder (PAMLD) was compared between 928 patients administered halothane and 1766 patients administered enflurane. They were selected from 19 504 surgical patients administered general anesthesia at Kyushu University Hospital over the past 6 years and 4 months. They had had normal liver function before operation and had no history of blood transfusion. Alanine aminotransferase (ALT) levels exceeding 70 IU. l(-1) within 180 days after operation were found in 226 patients in the halothane group (24.4%), and in 250 patients in the enflurane group (14.2%) ( P < 0.01). Both maximum ALT levels and duration of ALT elevation were higher and longer in the halothane group ( P < 0.01). These results suggest that, not only in the development of fulminant hepatitis but also in PAMLD, enflurane is less hepatotoxic than halothane.

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