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Gando S, Tedo I, Kubota M, et al. Changes in coagulation and fibrinolytic activity associated with tracheal intubation. J Anesth. 1992;6(1):80-4doi: 10.1007/s0054020060080.
Gando, S., Tedo, I., Kubota, M., & Tujinaga, H. (1992). Changes in coagulation and fibrinolytic activity associated with tracheal intubation. Journal of anesthesia, 6(1), 80-4. https://doi.org/10.1007/s0054020060080
Gando, S, et al. "Changes in coagulation and fibrinolytic activity associated with tracheal intubation." Journal of anesthesia vol. 6,1 (1992): 80-4. doi: https://doi.org/10.1007/s0054020060080
Gando S, Tedo I, Kubota M, Tujinaga H. Changes in coagulation and fibrinolytic activity associated with tracheal intubation. J Anesth. 1992 Jan;6(1):80-4. doi: 10.1007/s0054020060080. PMID: 15278588.
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J Anesth. 1992 Jan;6(1):80-4. doi: 10.1007/s0054020060080.

Changes in coagulation and fibrinolytic activity associated with tracheal intubation.

Journal of anesthesia

S Gando, I Tedo, M Kubota, H Tujinaga

Affiliations

  1. Department of Emergency and Critical Care Medicine, Sapporo National Hospital, Sapporo, Japan.

PMID: 15278588 DOI: 10.1007/s0054020060080

Abstract

This study was carried out to clarify the effect of tracheal intubation on the coagulation and fibrinolytic system. It was performed on 20 patients (ASA class 1-2) undergoing elective surgery. Before and after tracheal intubation, hemodynamics, ACTH, cortisol, catecholamines, and several coagulation and fibrinolytic factors were measured. Tracheal intubation was accompanied by significant increases in the blood pressure, heart rate, and norepinephrine level. No changes were observed in fibrinopetide A, fibrinopeptide B(Beta15-42), tissue plasminogen activator antigen, plasminogen, fibrinogen, and Alpha(2) plasmin inhibitor. Patients exposed to long intubation time (>20 seconds) were found to have a significantly higher level of fibrinopeptide A than patients with short tracheal intubation time (

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