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Kashimoto S, Oguchi T, Nakamura T, et al. Functional and metabolic effects of propafenone in the rat heart-lung preparation. J Anesth. 1991;5(4):392-5doi: 10.1007/s0054010050392.
Kashimoto, S., Oguchi, T., Nakamura, T., & Kumazawa, T. (1991). Functional and metabolic effects of propafenone in the rat heart-lung preparation. Journal of anesthesia, 5(4), 392-5. https://doi.org/10.1007/s0054010050392
Kashimoto, S, et al. "Functional and metabolic effects of propafenone in the rat heart-lung preparation." Journal of anesthesia vol. 5,4 (1991): 392-5. doi: https://doi.org/10.1007/s0054010050392
Kashimoto S, Oguchi T, Nakamura T, Kumazawa T. Functional and metabolic effects of propafenone in the rat heart-lung preparation. J Anesth. 1991 Oct;5(4):392-5. doi: 10.1007/s0054010050392. PMID: 15278609.
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J Anesth. 1991 Oct;5(4):392-5. doi: 10.1007/s0054010050392.

Functional and metabolic effects of propafenone in the rat heart-lung preparation.

Journal of anesthesia

S Kashimoto, T Oguchi, T Nakamura, T Kumazawa

Affiliations

  1. Department of Anesthesia, Kohfu City Hospital, Yamanashi, Japan.

PMID: 15278609 DOI: 10.1007/s0054010050392

Abstract

The effects of propafenone on cardiac function and myocardial metabolism were assessed in the isolated rat heart-lung preparation. Propafenone 0.3, 3 or 30 microg.ml(-1) was administered 5 min after the start of perfusion. Heart rate decreased in the 30 microg.ml(-1) group significantly following the drug administration. The highest dose of propafenone (30 microg.ml(-1)) reduced cardiac output significantly, and this dose was associated with a higher incidence of arrhythmias than the other groups. Although there were no significant differences in myocardial lactate and glycogen concentrations among groups, ATP content in the 30 microg.ml(-1) group was significantly less than that in the control group. As therapeutic plasma concentration of propafenone is about 0.6 (range 0.06 to 1.0) microg.ml(-1), 30 microg.ml(-1) is 50 times greater than its concentration. These results suggest that the negative inotropic and chronotropic effects of propafenone are almost same with those of lidocaine which we have previously reported.

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