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Baek WY, Hatano Y, Nakamura K, et al. Age-dependent alterations in the response of isolated rat aortas to thiobarbiturates. J Anesth. 1991;5(2):199-202doi: 10.1007/s0054010050199.
Baek, W. Y., Hatano, Y., Nakamura, K., Nishiwada, M., & Mori, K. (1991). Age-dependent alterations in the response of isolated rat aortas to thiobarbiturates. Journal of anesthesia, 5(2), 199-202. https://doi.org/10.1007/s0054010050199
Baek, W Y, et al. "Age-dependent alterations in the response of isolated rat aortas to thiobarbiturates." Journal of anesthesia vol. 5,2 (1991): 199-202. doi: https://doi.org/10.1007/s0054010050199
Baek WY, Hatano Y, Nakamura K, Nishiwada M, Mori K. Age-dependent alterations in the response of isolated rat aortas to thiobarbiturates. J Anesth. 1991 Apr;5(2):199-202. doi: 10.1007/s0054010050199. PMID: 15278659.
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J Anesth. 1991 Apr;5(2):199-202. doi: 10.1007/s0054010050199.

Age-dependent alterations in the response of isolated rat aortas to thiobarbiturates.

Journal of anesthesia

W Y Baek, Y Hatano, K Nakamura, M Nishiwada, K Mori

Affiliations

  1. Department of Anesthesiology, Kyungpook National University Hospital, Taegu, Korea.

PMID: 15278659 DOI: 10.1007/s0054010050199

Abstract

Responses to thiamylal and thiopental were compared in helical strips of rat thoracic aortas of different ages (5-6, 10-12 and 20-22 weeks old), precontracted partially with phenylephrine or prostaglandin F(2alpha) (PGF(2alpha)). Thiamylal and thiopental, in concentrations of 3 x 10(-5) to 10(-4) M, produced a dose-dependent relaxation in aortas at 5-6 weeks of age, no significant change of tension in those at 10-12 weeks of age, and a marked constriction in those at 20-22 weeks of age. These thiobarbiturates, in a high concentration of 10(-3) M, produced a profound relaxation in aortas at any age studied. It is concluded that the responses to thiobarbiturates of thoracic aorta precontracted with phenylephrine or PGF(2alpha) alter with age.

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