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Endocr Pract. 1997 Sep-Oct;3(5):293-6. doi: 10.4158/EP.3.5.293.

Misleading acute hypercalcemia due to hyperlipidemia: a method-dependent error.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

I Sachmechi, G Shah, L Rezainadimi, D A Blaustein, F Rosner

Affiliations

  1. Department of Medicine, Division of Endocrinology, Mount Sinai Services at Queens Hospital Center, Jamaica, New York 11432, USA.

PMID: 15251784 DOI: 10.4158/EP.3.5.293

Abstract

OBJECTIVE: To report a case of artifactual hypercalcemia in a patient with hyperlipidemia.

METHODS: We present clinical data and laboratory findings in a 33-year-old woman with generalized fatigue, a recent 5-kg weight loss, and a papular rash on the extremities as well as a history of diabetes and hypertension.

RESULTS: Physical examination revealed an obese patient with eruptive xanthomas and lipemia retinalis. Laboratory tests showed hyperlipidemia, hypercalcemia (serum calcium measured by spectrophotometry), anemia, hyperproteinemia, hyperuricemia, and hyperbilirubinemia. After 4 days of a low-fat, low-cholesterol diet and gemfibrozil therapy, the serum triglyceride level decreased, and the serum calcium concentration returned to normal.

CONCLUSION: In patients with hypercalcemia without an obvious cause, a spurious measurement should be considered.

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