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Barbucci R, Pasqui D, Wirsen A, et al. Micro and nano-structured surfaces. J Mater Sci Mater Med. 2003;14(8):721-5doi: 10.1023/a:1024919917969.
Barbucci, R., Pasqui, D., Wirsen, A., Affrossman, S., Curtis, A., & Tetta, C. (2003). Micro and nano-structured surfaces. Journal of materials science. Materials in medicine, 14(8), 721-5. https://doi.org/10.1023/a:1024919917969
Barbucci, R, et al. "Micro and nano-structured surfaces." Journal of materials science. Materials in medicine vol. 14,8 (2003): 721-5. doi: https://doi.org/10.1023/a:1024919917969
Barbucci R, Pasqui D, Wirsen A, Affrossman S, Curtis A, Tetta C. Micro and nano-structured surfaces. J Mater Sci Mater Med. 2003 Aug;14(8):721-5. doi: 10.1023/a:1024919917969. PMID: 15348415.
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J Mater Sci Mater Med. 2003 Aug;14(8):721-5. doi: 10.1023/a:1024919917969.

Micro and nano-structured surfaces.

Journal of materials science. Materials in medicine

R Barbucci, D Pasqui, A Wirsen, S Affrossman, A Curtis, C Tetta

Affiliations

  1. C.R.I.S.M.A., University of Siena, Via A. Moro, 53100 Siena, Italy. [email protected]

PMID: 15348415 DOI: 10.1023/a:1024919917969

Abstract

The study of cell reaction to micro and nanotopography is dependent on the method of manufacture available. Several methods of manufacture have been developed: polymer demixing, embossing and photolithography. Surfaces obtained with these different techniques, having micro and/or nanodomains, have been studied toward the same type of cells, i.e. human endothelial cells (HGTFN) and mouse fibroblasts (3T3). Polymer demixing of polystyrene (PS) and poly(4-bromostyrene) (PBrS) producing nanometrically islands of 18, 45 and 100 nm height, polycarbonate (PC) and polycaprolactone (PCL) grooved with grooves 450 nm wide and 190 high, the natural polysaccharide hyaluronic acid (Hyal) and its sulfated derivative (HyalS) photoimmobilized on silanized glass as grooves 250 nm high and 100, 50, 25 or 10 microm wide have been obtained. The morphology and polarization of the cells has been studied by optical microscopy and scanning electron microscopy. Cells respond in different way to the topography of the materials, but the surface chemistry is dominant in inducing different cell behavior.

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