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Ekholm M, Hietanen J, Tulamo RM, et al. Tissue reactions of subcutaneously implanted mixture of epsilon-caprolactone-lactide copolymer and tricalcium phosphate. An electron microscopic evaluation in sheep. J Mater Sci Mater Med. 2003;14(10):913-8doi: 10.1023/a:1025642912270.
Ekholm, M., Hietanen, J., Tulamo, R. M., Muhonen, J., Lindqvist, C., Kellomäki, M., & Suuronen, R. (2003). Tissue reactions of subcutaneously implanted mixture of epsilon-caprolactone-lactide copolymer and tricalcium phosphate. An electron microscopic evaluation in sheep. Journal of materials science. Materials in medicine, 14(10), 913-8. https://doi.org/10.1023/a:1025642912270
Ekholm, Marja, et al. "Tissue reactions of subcutaneously implanted mixture of epsilon-caprolactone-lactide copolymer and tricalcium phosphate. An electron microscopic evaluation in sheep." Journal of materials science. Materials in medicine vol. 14,10 (2003): 913-8. doi: https://doi.org/10.1023/a:1025642912270
Ekholm M, Hietanen J, Tulamo RM, Muhonen J, Lindqvist C, Kellomäki M, Suuronen R. Tissue reactions of subcutaneously implanted mixture of epsilon-caprolactone-lactide copolymer and tricalcium phosphate. An electron microscopic evaluation in sheep. J Mater Sci Mater Med. 2003 Oct;14(10):913-8. doi: 10.1023/a:1025642912270. PMID: 15348530.
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J Mater Sci Mater Med. 2003 Oct;14(10):913-8. doi: 10.1023/a:1025642912270.

Tissue reactions of subcutaneously implanted mixture of epsilon-caprolactone-lactide copolymer and tricalcium phosphate. An electron microscopic evaluation in sheep.

Journal of materials science. Materials in medicine

Marja Ekholm, Jarkko Hietanen, Riitta-Mari Tulamo, Jarkko Muhonen, Christian Lindqvist, Minna Kellomäki, Riitta Suuronen

Affiliations

  1. Department of Oral and Maxillofacial Surgery, Helsinki University Central Hospital, Finland.

PMID: 15348530 DOI: 10.1023/a:1025642912270

Abstract

Biodegradable polymers, mainly derivates of alpha-hydroxy acids, are widely used today in oral- and maxillofacial surgery, orthopedics, and other fields of surgery. These biomaterials are well tolerated by living tissue and fracture fixation devices made of polylactic or polyglycolic acid are clinically widely used today. Still, there are some problems in application of biodegradable polymers. Abacterial inflammatory reactions have been noticed after the clinical introduction of these devices. Both swelling and pain at the site of implantation have also been reported. The etiology of this inflammatory reaction is still unknown, despite the numerous studies. Therefore, the aim of the present study was to further characterize this inflammatory reaction in detail, by electronmicroscopy. We prepared a mixture of epsilon-caprolactone-lactide copolymer and tricalcium phosphate and placed it in the dermis in 12 sheep. Follow-up times were 9, 14, 24, and 52 weeks. We found that the mixture caused a mild inflammatory reaction. There were no signs of cell damage. Fibroblasts, macrophages, and eosinophils were found adjacent to the copolymer. The mixture is easy to handle and can be moulded into different shapes in room temperature. The results encourage us to continue our studies to develop a filling material for bone defects.

References

  1. Biomaterials. 1999 Jul;20(14):1257-62 - PubMed
  2. Microsurgery. 1993;14(8):508-15 - PubMed
  3. Biomaterials. 1997 Apr;18(8):613-22 - PubMed
  4. Microsurgery. 1996;17(10):555-61 - PubMed
  5. J Bone Joint Surg Br. 1990 Jul;72(4):592-6 - PubMed
  6. J Biomed Mater Res. 1996 May;31(1):105-15 - PubMed
  7. Microsurgery. 1999;19(5):247-53 - PubMed
  8. J Oral Maxillofac Surg. 1993 Jun;51(6):666-70 - PubMed
  9. J Biomed Mater Res. 1995 Jun;29(6):757-66 - PubMed
  10. J Periodontol. 1998 Jan;69(1):54-61 - PubMed
  11. J Biomed Mater Res. 1997 Sep 5;36(3):337-46 - PubMed
  12. Crit Rev Clin Lab Sci. 1999 Oct;36(5):453-96 - PubMed
  13. Biomaterials. 1995 Mar;16(4):267-74 - PubMed
  14. J Biomed Mater Res. 1997 Jan;34(1):39-46 - PubMed
  15. J Mater Sci Mater Med. 1999 Feb;10(2):69-74 - PubMed
  16. Oral Surg Oral Med Oral Pathol. 1982 Nov;54(5):499-505 - PubMed
  17. J Neurosurg. 1997 Jun;86(6):1012-7 - PubMed
  18. Clin Orthop Relat Res. 1992 May;(278):193-9 - PubMed
  19. Biomaterials. 1990 May;11(4):286-90 - PubMed
  20. J Bone Joint Surg Br. 1990 Jul;72(4):597-600 - PubMed

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