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Skipor AK, Campbell PA, Patterson LM, et al. Serum and urine metal levels in patients with metal-on-metal surface arthroplasty. J Mater Sci Mater Med. 2002;13(12):1227-34doi: 10.1023/a:1021179029640.
Skipor, A. K., Campbell, P. A., Patterson, L. M., Anstutz, H. C., Schmalzried, T. P., & Jacobs, J. J. (2002). Serum and urine metal levels in patients with metal-on-metal surface arthroplasty. Journal of materials science. Materials in medicine, 13(12), 1227-34. https://doi.org/10.1023/a:1021179029640
Skipor, Anastasia K, et al. "Serum and urine metal levels in patients with metal-on-metal surface arthroplasty." Journal of materials science. Materials in medicine vol. 13,12 (2002): 1227-34. doi: https://doi.org/10.1023/a:1021179029640
Skipor AK, Campbell PA, Patterson LM, Anstutz HC, Schmalzried TP, Jacobs JJ. Serum and urine metal levels in patients with metal-on-metal surface arthroplasty. J Mater Sci Mater Med. 2002 Dec;13(12):1227-34. doi: 10.1023/a:1021179029640. PMID: 15348670.
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J Mater Sci Mater Med. 2002 Dec;13(12):1227-34. doi: 10.1023/a:1021179029640.

Serum and urine metal levels in patients with metal-on-metal surface arthroplasty.

Journal of materials science. Materials in medicine

Anastasia K Skipor, Patricia A Campbell, Leslie M Patterson, Harlan C Anstutz, Thomas P Schmalzried, Joshua J Jacobs

Affiliations

  1. Department of Orthopedic Surgery, Room 756, Cohn Research Building, Rush Presbyterian, St. Luke's Medical Center, 1735 West Harrison St., Chicago, IL 60612-3833, USA. [email protected]

PMID: 15348670 DOI: 10.1023/a:1021179029640

Abstract

The resurgence of metal-on-metal articulating surfaces for hip arthroplasty has also heightened concerns about the degree and magnitude of metal particle generation and the accompanying increase in circulating metal ion concentrations. In this study, we measured the concentration of chromium in serum and urine and the concentration of cobalt in serum in twenty-five patients with modern metal-on-metal surface arthroplasty of the hip in a prospective manner. The results showed that the mean post-operative chromium in serum levels were 22-fold, 23-fold and 21-fold higher at 3, 6 and 12 months post-operative, respectively, than pre-operative levels. The mean post-operative cobalt in serum levels were 8-fold, 7-fold and 6-fold higher at 3, 6 and 12 months post-operative, respectively, than pre-operative levels. The mean post-operative chromium in urine levels were 9-fold, 10-fold and 14-fold higher at 3, 6 and 12 months post-operative, respectively, than pre-operative levels. The values seen in this study with the current generation of surface arthroplasties are: (a) lower than those seen in an earlier generation of surface arthroplasties; (b) in the same range as those observed in association with metal-on-metal conventional total hip replacements, which typically have smaller head sizes; (c) higher than values observed in patients with conventional metal-on-polyethylene articulating couples.

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