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Dourakis SP, Alexopoulou A, Papageorgiou C, et al. Acute chest syndrome in sickle-cell trait; Two case reports in persons of Mediterranean origin and review of the literature. Eur J Intern Med. 2004;15(4):248-250doi: 10.1016/j.ejim.2004.03.010.
Dourakis, S. P., Alexopoulou, A., Papageorgiou, C., Kaloterakis, A., & Hadziyannis, S. J. (2004). Acute chest syndrome in sickle-cell trait; Two case reports in persons of Mediterranean origin and review of the literature. European journal of internal medicine, 15(4), 248-250. https://doi.org/10.1016/j.ejim.2004.03.010
Dourakis, Spyros P., et al. "Acute chest syndrome in sickle-cell trait; Two case reports in persons of Mediterranean origin and review of the literature." European journal of internal medicine vol. 15,4 (2004): 248-250. doi: https://doi.org/10.1016/j.ejim.2004.03.010
Dourakis SP, Alexopoulou A, Papageorgiou C, Kaloterakis A, Hadziyannis SJ. Acute chest syndrome in sickle-cell trait; Two case reports in persons of Mediterranean origin and review of the literature. Eur J Intern Med. 2004 Jul;15(4):248-250. doi: 10.1016/j.ejim.2004.03.010. PMID: 15288680.
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Eur J Intern Med. 2004 Jul;15(4):248-250. doi: 10.1016/j.ejim.2004.03.010.

Acute chest syndrome in sickle-cell trait; Two case reports in persons of Mediterranean origin and review of the literature.

European journal of internal medicine

Spyros P. Dourakis, Alexandra Alexopoulou, Constantin Papageorgiou, Andreas Kaloterakis, Stephanos J. Hadziyannis

Affiliations

  1. Academic Department of Medicine, Hippokration General Hospital, Athens, Greece.

PMID: 15288680 DOI: 10.1016/j.ejim.2004.03.010

Abstract

Sickle-cell trait has been characterized as a benign condition. However, life-threatening complications sometimes develop. Acute chest syndrome (ACS) is usually described in homozygous sickle cell disease, but it rarely develops in individuals with sickle-cell trait. Two cases of ACS in patients with sickle-cell trait are reported here. Factors such as advanced age at the time of presentation and absent past medical and family history can be misleading. Although ACS in sickle-cell trait has thus far only been reported in persons of Afro-American origin, persons of Mediterranean origin can, on rare occasions, also experience the syndrome.

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