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Dourado M, Alves V, Mesquita L, et al. CD26/DPPIV and response to hepatitis B vaccination. Pathophysiology. 2004;11(3):147-152doi: 10.1016/j.pathophys.2004.06.002.
Dourado, M., Alves, V., Mesquita, L., Ramos, I., Pinto, A. M., & Rosa, M. S. (2004). CD26/DPPIV and response to hepatitis B vaccination. Pathophysiology : the official journal of the International Society for Pathophysiology, 11(3), 147-152. https://doi.org/10.1016/j.pathophys.2004.06.002
Dourado, Marília, et al. "CD26/DPPIV and response to hepatitis B vaccination." Pathophysiology : the official journal of the International Society for Pathophysiology vol. 11,3 (2004): 147-152. doi: https://doi.org/10.1016/j.pathophys.2004.06.002
Dourado M, Alves V, Mesquita L, Ramos I, Pinto AM, Rosa MS. CD26/DPPIV and response to hepatitis B vaccination. Pathophysiology. 2004 Dec;11(3):147-152. doi: 10.1016/j.pathophys.2004.06.002. PMID: 15561511.
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Pathophysiology. 2004 Dec;11(3):147-152. doi: 10.1016/j.pathophys.2004.06.002.

CD26/DPPIV and response to hepatitis B vaccination.

Pathophysiology : the official journal of the International Society for Pathophysiology

Marília Dourado, Vera Alves, Luis Mesquita, Isabel Ramos, Anabela Mota Pinto, Manuel Santos Rosa

Affiliations

  1. Institute of General Pathology, Faculty of Medicine, University of Coimbra, Rua Larga, 3004-504 Coimbra, Portugal.

PMID: 15561511 DOI: 10.1016/j.pathophys.2004.06.002

Abstract

The prevention of hepatitis B is important, since it is responsible for significant morbidity and mortality around the world. Unfortunately, hepatitis B vaccine does not always induce protective immunity. The lack of immune response to vaccine (non-responders) can depend on individual characteristics. The objective of this study was to correlate the CD26/DPPIV cellular expression and DPPIV serum activity with HBV vaccine response and its possible role as an indicator of immune competence acquisition. We also determined the cellular expression of CD3, CD19, CD56 and CD25 in peripheral blood T lymphocytes. Blood samples were obtained from 28 healthy human volunteers who were enrolled with a vaccination program. There were "responders" (RM = 13) and "non-responders" (NRM = 15), after vaccination. The lymphocyte populations were identified by flow cytometry. DPPIV serum activity was measured fluorimetrically. CD26 expression in responders (55.9 +/- 7.7%) versus in non-responders (51.9 +/- 7.0%) did not show a significant difference. The DPPIV serum activity in responders compared to in non-responder subgroup (59.9 +/- 8.4/50.3 +/- 10.6U/L) showed, however, a significant difference (P < 0.05). The expression of CD3, CD19 and CD56 on peripheral lymphocytes was similar between responders and non-responders. The expression of CD3CD26 (52.2 +/- 8.6%) and CD3CD25 (10.9 +/- 3.8%) in responders versus the expression of CD3CD26 (48.0 +/- 5.7%) and CD3CD25 (8 +/- 4.6%) in non-responders did not show statistically significant difference. CD25 referred as a marker of T lymphocyte activation was increased in responders (15.8 +/- 4.5%) versus in non-responders (10.1 +/- 4.8%), showing a significant difference (P = 0.003). It was, however, impossible to demonstrate an increase in CD3CD25 and CD3CD26 in the responder subgroup. This suggests that different lymphocyte subsets other than T cells are implicated in the response to hepatitis B vaccination.

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