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Barrington JW, Linton D, O'Leary A, et al. Anaerobic (bacterial) vaginosis and premalignant disease of the cervix. J Obstet Gynaecol. 1997;17(4):383-5doi: 10.1080/01443619750112943.
Barrington, J. W., Linton, D., O'Leary, A., Blackwell, A., Brick, J., & Calvert, J. P. (1997). Anaerobic (bacterial) vaginosis and premalignant disease of the cervix. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 17(4), 383-5. https://doi.org/10.1080/01443619750112943
Barrington, J W, et al. "Anaerobic (bacterial) vaginosis and premalignant disease of the cervix." Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology vol. 17,4 (1997): 383-5. doi: https://doi.org/10.1080/01443619750112943
Barrington JW, Linton D, O'Leary A, Blackwell A, Brick J, Calvert JP. Anaerobic (bacterial) vaginosis and premalignant disease of the cervix. J Obstet Gynaecol. 1997 Jun;17(4):383-5. doi: 10.1080/01443619750112943. PMID: 15511897.
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J Obstet Gynaecol. 1997 Jun;17(4):383-5. doi: 10.1080/01443619750112943.

Anaerobic (bacterial) vaginosis and premalignant disease of the cervix.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

J W Barrington, D Linton, A O'Leary, A Blackwell, J Brick, J P Calvert

Affiliations

  1. Department of Obstetrics and Gynaecology, Singleton Hospital, Swansea, UK.

PMID: 15511897 DOI: 10.1080/01443619750112943

Abstract

Nitrosamines are carcinogenic substances found in cigarette smoke, and it is known that female smokers have an increased risk of cervical carcinoma and premalignant change. Nitrosamines may also be formed due to the combination of amines and nitrites in an acidic medium. This study has shown a statistically significant association between anaerobic vaginosis which produce amines and cervical intraepithelial neoplasia 2 and 3. In addition nitrate reducing organisms are found in the acidic lower genital tract in a significant number of cases. It is therefore theoretically possible that nitrosamines may be an important agent in the development of premalignant disease of the cervix.

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