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J Obstet Gynaecol. 2000 Jan;20(1):65-7. doi: 10.1080/01443610063507.

Can a single serum CA125 assay predict the outcome of threatened abortion?.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

L S Sherif, A G El-Metwaly, H Shalan, A M Badawy, E Abu-Hashem

Affiliations

  1. Department of Obstetrics and Gynaecology, Mansoura Faculty of Medicine, Mansoura University, Egypt.

PMID: 15512471 DOI: 10.1080/01443610063507

Abstract

Earlier work suggested that high levels of CA125 could be detected in the sera of women with threatened abortion. In this study, we used CA125 as a method of anticipating outcome in cases of threatened abortion and compared the results with ultrasonic findings. Three groups of patients were studied.(1) 57 women who threatened to abort, but whose pregnancy continued.(2) 43 women with a threatened abortion, who subsequently aborted, and (3) 50 normal women who had no bleeding in early pregnancy. There was a highly significant increase in serum CA125 in women who aborted compared with the other two groups (P<0.001). The results compared well with conventional ultrasound and serum CA125 may be developed as a cheap, sensitive and specific predictor of outcome in cases of threatened abortion.

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