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Wan CL, Ahang TM, Wang L, et al. [Role of uncoupling proteins in the pathogenesis of obesity and type II diabetes]. Yi Chuan. 2003;25(2):211-20
Wan, C. L., Ahang, T. M., Wang, L., Yang, Z., & Feng, F. (2003). [Role of uncoupling proteins in the pathogenesis of obesity and type II diabetes]. Yi chuan = Hereditas, 25(2), 211-20.
Wan, Chun-Ling, et al. "[Role of uncoupling proteins in the pathogenesis of obesity and type II diabetes]." Yi chuan = Hereditas vol. 25,2 (2003): 211-20.
Wan CL, Ahang TM, Wang L, Yang Z, Feng F. [Role of uncoupling proteins in the pathogenesis of obesity and type II diabetes]. Yi Chuan. 2003 Mar;25(2):211-20. Chinese. PMID: 15639857.
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Yi Chuan. 2003 Mar;25(2):211-20.

[Role of uncoupling proteins in the pathogenesis of obesity and type II diabetes].

Yi chuan = Hereditas

[Article in Chinese]
Chun-Ling Wan, Tie-Mei Ahang, Li Wang, Ze Yang, Feng Feng

Affiliations

  1. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

PMID: 15639857

Abstract

Uncoupling proteins (UCPs) are mitochondria carrier proteins,which are able to dissipate the proton gradient of the inner mitochondria membrane. The uncoupling procedure reduces the amount of ATP generated through an oxidation of fuels. Therefore, UCPs are suggested as candidate genes for human obesity or type II diabetes mellitus. Experimental evidences,that genetically engineered mice over expressing different UCP homologues were resistant to diet-induced obesity and 45 bp insertion polymorphism in the UCP2 3' untranslated region and C-55T in UCP3 promoter region were associated with obesity related phenotype, supported the hypothesis. The roles of UCP genes in polygenic obesity and type II diabetes are evaluated and discussed in this paper.

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