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Love JT, Nemoto EM, Yonas H, et al. Effect of stable xenon inhalation on internal carotid artery blood flow in unanesthetized monkeys. J Neurosurg Anesthesiol. 1992;4(4):257-60doi: 10.1097/00008506-199210000-00005.
Love, J. T., Nemoto, E. M., Yonas, H., Darby, J. M., & Melick, J. A. (1992). Effect of stable xenon inhalation on internal carotid artery blood flow in unanesthetized monkeys. Journal of neurosurgical anesthesiology, 4(4), 257-60. https://doi.org/10.1097/00008506-199210000-00005
Love, J T, et al. "Effect of stable xenon inhalation on internal carotid artery blood flow in unanesthetized monkeys." Journal of neurosurgical anesthesiology vol. 4,4 (1992): 257-60. doi: https://doi.org/10.1097/00008506-199210000-00005
Love JT, Nemoto EM, Yonas H, Darby JM, Melick JA. Effect of stable xenon inhalation on internal carotid artery blood flow in unanesthetized monkeys. J Neurosurg Anesthesiol. 1992 Oct;4(4):257-60. doi: 10.1097/00008506-199210000-00005. PMID: 15815474.
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J Neurosurg Anesthesiol. 1992 Oct;4(4):257-60. doi: 10.1097/00008506-199210000-00005.

Effect of stable xenon inhalation on internal carotid artery blood flow in unanesthetized monkeys.

Journal of neurosurgical anesthesiology

J T Love, E M Nemoto, H Yonas, J M Darby, J A Melick

Affiliations

  1. Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

PMID: 15815474 DOI: 10.1097/00008506-199210000-00005

Abstract

Stable xenon (Xe) gas, at inspired concentrations above 30%, reportedly increased cerebral blood flow (CBF) in animals and humans. An unpredictable Xe-induced elevation of CBF could result in erroneous CBF values being measured by Xe-enhanced computed tomography (Xe-CT). In order to detect a potentially rapid and transient effect of Xe on CBF, estimations of supratentorial CBF were obtained by Doppler flow probes chronically and bilaterally implanted on the internal carotid arteries of five adult monkeys. The unanesthetized monkeys with a clear plastic helmet were equilibrated for 15 min on a control gas (33% N2/67% O2) randomly exposed for 5 min to gas mixtures of either 33% Xe/67% O2 or 10% CO2/23% N2/67% O2. The mean control bilateral internal carotid artery blood flow (ICABF) was 23 +/- 10 ml/min (mean +/- SD), mean arterial pressure (MAP) was 101 +/- 13 mm Hg, and PaCO2 was 34 +/- 6 mm Hg. Inhalation of 33% Xe in O2 did not change the ICABF, MAP, or PaCO2. Inhalation of 10% CO2 in O2 increased the ICABF to 39 +/- 15 ml/min (p <0.001), MAP to 112 +/- 16 mm Hg (p <0.05), and PaCO2 to 54 +/- 5 mm Hg (p <0.001). The lack of change in ICABF and PaCO2 with 32% Xe inhalation suggests that a clinically relevant change in CBF is unlikely.

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