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Wada A, Sakaeda T, Takara K, et al. Effects of St John's wort and hypericin on cytotoxicity of anticancer drugs. Drug Metab Pharmacokinet. 2002;17(5):467-74doi: 10.2133/dmpk.17.467.
Wada, A., Sakaeda, T., Takara, K., Hirai, M., Kimura, T., Ohmoto, N., Zhou, J., Nakamura, T., Kobayashi, H., Okamura, N., Yagami, T., & Okumura, K. (2002). Effects of St John's wort and hypericin on cytotoxicity of anticancer drugs. Drug metabolism and pharmacokinetics, 17(5), 467-74. https://doi.org/10.2133/dmpk.17.467
Wada, Atsushi, et al. "Effects of St John's wort and hypericin on cytotoxicity of anticancer drugs." Drug metabolism and pharmacokinetics vol. 17,5 (2002): 467-74. doi: https://doi.org/10.2133/dmpk.17.467
Wada A, Sakaeda T, Takara K, Hirai M, Kimura T, Ohmoto N, Zhou J, Nakamura T, Kobayashi H, Okamura N, Yagami T, Okumura K. Effects of St John's wort and hypericin on cytotoxicity of anticancer drugs. Drug Metab Pharmacokinet. 2002;17(5):467-74. doi: 10.2133/dmpk.17.467. PMID: 15618698.
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Drug Metab Pharmacokinet. 2002;17(5):467-74. doi: 10.2133/dmpk.17.467.

Effects of St John's wort and hypericin on cytotoxicity of anticancer drugs.

Drug metabolism and pharmacokinetics

Atsushi Wada, Toshiyuki Sakaeda, Kohji Takara, Midori Hirai, Takashi Kimura, Nobuko Ohmoto, Jie Zhou, Tsutomu Nakamura, Hironao Kobayashi, Noboru Okamura, Tatsurou Yagami, Katsuhiko Okumura

Affiliations

  1. Department of Clinical Pharmacy, Kobe Pharmaceutical University, Japan.

PMID: 15618698 DOI: 10.2133/dmpk.17.467

Abstract

St John's wort (SJW) is Hypericum perforatum L., Hypericaceae, a herbaceous perennial plant native to Europe and Asia, and its various preparations are widely used for the treatment of mild-to-moderately severe depressive disorders. With increasingly prevalent use, the interactions with SJW preparations with co-administered drugs have been reported, presumably via MDR1-mediated processes. In this paper, the effects of SJW extract on antiproliferative effects of anticancer drugs and the expression of MDR1 mRNA were examined using HeLa and its MDR1-overexpressing subline. The effects on MDR1-mediated transport were also evaluated using [(3)H]digoxin and LLC-GA5-COL150 cells, which were established by transfection of human MDR1 cDNA into porcine kidney epithelial LLC-PK(1) cells. The content of hypericin, a presumed active moiety within SJW extract, was determined by HPLC with a photo diode array to be 0.085 (w/w)%, and the effects of hypericin were also evaluated and compared with those of SJW extract. It was concluded that SJW extract reversed the cytotoxicity of paclitaxel and slightly of daunorubicin, down-regulated MDR1 mRNA, and inhibited MDR1-mediated transport, presumably due to other components than hypericin.

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