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Calverley DC, Varteresian T, Brass E, et al. Association between monocyte Fcgamma subclass expression and acute coronary syndrome. Immun Ageing. 2004;1(1):4doi: 10.1186/1742-4933-1-4.
Calverley, D. C., Varteresian, T., Brass, E., Tsao-Wei, D. D., Groshen, S., Mack, W. J., Buchanan, T. A., Hodis, H. N., & Schreiber, A. D. (2004). Association between monocyte Fcgamma subclass expression and acute coronary syndrome. Immunity & ageing : I & A, 1(1), 4. https://doi.org/10.1186/1742-4933-1-4
Calverley, David C, et al. "Association between monocyte Fcgamma subclass expression and acute coronary syndrome." Immunity & ageing : I & A vol. 1,1 (2004): 4. doi: https://doi.org/10.1186/1742-4933-1-4
Calverley DC, Varteresian T, Brass E, Tsao-Wei DD, Groshen S, Mack WJ, Buchanan TA, Hodis HN, Schreiber AD. Association between monocyte Fcgamma subclass expression and acute coronary syndrome. Immun Ageing. 2004 Nov 12;1(1):4. doi: 10.1186/1742-4933-1-4. PMID: 15679933; PMCID: PMC544957.
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Immun Ageing. 2004 Nov 12;1(1):4. doi: 10.1186/1742-4933-1-4.

Association between monocyte Fcgamma subclass expression and acute coronary syndrome.

Immunity & ageing : I & A

David C Calverley, Taya Varteresian, Elizabeth Brass, Denice D Tsao-Wei, Susan Groshen, Wendy J Mack, Thomas A Buchanan, Howard N Hodis, Alan D Schreiber

Affiliations

  1. Department of Medicine, University of Colorado, Denver, CO; USA. [email protected].

PMID: 15679933 PMCID: PMC544957 DOI: 10.1186/1742-4933-1-4

Abstract

BACKGROUND: Atherosclerosis lesions contain abundant immunoglobulins complexed with oxidized LDL (OxLDL) that are endocytosed by macrophages to form foam cells. While recent evidence supports a role for the macrophage scavenger receptor pathway in 75-90% of OxLDL uptake, in vitro evidence suggests another potential uptake pathway could involve autoantibody binding to IgG subclass-specific Fc receptors. OBJECTIVE AND METHODS: To address this mechanism from an in vivo standpoint, the objective of this study was to utilize flow cytometry to prospectively determine monocyte Fcgamma (FcR) I, II, and III receptor expression levels in patients with acute coronary syndrome (ACS, n = 48), diabetes mellitus (DM, n = 59), or neither (C, n = 88). RESULTS: Increased FcR I expression was found in the ACS versus DM groups [geometric mean, (95% CI) = 2.26 (2.07, 2.47) versus 1.83 (1.69, 1.98) (p < 0.001)] and versus C [1.90 (1.78, 2.03) (p = 0.005)]. Similar relationships were found with both the FcR II receptor [ACS mean = 4.57 (4.02, 5.19) versus DM 3.61 (3.22, 4.05) (p = 0.021) and versus C 3.86 (3.51, 4.24) (p = 0.09)] and FcR III receptor [ACS mean = 1.55 (1.44, 1.68) versus DM 1.36 (1.27, 1.46) (p = 0.038) and versus C 1.37 (1.30, 1.45) (p = 0.032)]. There was no difference between DM and C groups in FcR I, II or III expression. CONCLUSIONS: This in vivo data supports a possible second OxLDL-autoantibody macrophage uptake mechanism through an Fc receptor-mediated pathway and a potential relationship between atherosclerotic plaque macrophage FcR levels and ACS.

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