J Chromatogr A. 2005 Mar 04;1067(1):285-94. doi: 10.1016/j.chroma.2004.11.008.

Towards smaller and faster gas chromatography-mass spectrometry systems for field chemical detection.

Journal of chromatography. A

P A Smith, M T Sng, B A Eckenrode, S Y Leow, D Koch, R P Erickson, C R Jackson Lepage, G L Hook

PMID: 15844534 DOI: 10.1016/j.chroma.2004.11.008

Abstract

Gas chromatography-mass spectrometry (GC-MS) is already an important laboratory method, but new sampling techniques and column heating approaches will expand and improve its usefulness for detection and identification of unknown chemicals in field settings. In order to demonstrate commercially-available technical advances for both sampling and column heating, we used solid phase microextraction (SPME) sampling of both water and air systems, followed by immediate analysis with a resistively heated analytical column and mass spectrometric detection. High-concern compounds ranging from 140 to 466 amu were analyzed to show the applicability of these techniques to emergency situations impacting public health. A field portable (about 35 kg) GC-MS system was used for analysis of water samples with a resistively heated analytical column externally mounted as a retrofit using the air bath oven of the original instrument design to heat transfer lines. The system used to analyze air samples included a laboratory mass spectrometer with a dedicated resistive column heating arrangement (no legacy air bath column oven). The combined sampling and analysis time was less than 10 min for both air and water sample types. By combining dedicated resistive column heating with smaller mass spectrometry systems designed specificallyfor use in the field, substantially smaller high performance field-portable instrumentation will be possible.

MeSH terms

• Gas Chromatography-Mass Spectrometry / methods

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't
• Research Support, U.S. Gov't, Non-P.H.S.