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El-Mahallawy HA, Bahgat N, El-Din HM, et al. Hepatitis C virus and its genotypes and Helicobacter pylori in pediatric non-Hodgkin's lymphoma: could there be a possible etiologic role?. J Egypt Natl Canc Inst. 2004;16(2):114-22
El-Mahallawy, H. A., Bahgat, N., El-Din, H. M., Farag, S. A., Nouh, A., & El-Attar, I. (2004). Hepatitis C virus and its genotypes and Helicobacter pylori in pediatric non-Hodgkin's lymphoma: could there be a possible etiologic role?. Journal of the Egyptian National Cancer Institute, 16(2), 114-22.
El-Mahallawy, Hadir Ahmed, et al. "Hepatitis C virus and its genotypes and Helicobacter pylori in pediatric non-Hodgkin's lymphoma: could there be a possible etiologic role?." Journal of the Egyptian National Cancer Institute vol. 16,2 (2004): 114-22.
El-Mahallawy HA, Bahgat N, El-Din HM, Farag SA, Nouh A, El-Attar I. Hepatitis C virus and its genotypes and Helicobacter pylori in pediatric non-Hodgkin's lymphoma: could there be a possible etiologic role?. J Egypt Natl Canc Inst. 2004 Jun;16(2):114-22. PMID: 15912152.
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J Egypt Natl Canc Inst. 2004 Jun;16(2):114-22.

Hepatitis C virus and its genotypes and Helicobacter pylori in pediatric non-Hodgkin's lymphoma: could there be a possible etiologic role?.

Journal of the Egyptian National Cancer Institute

Hadir Ahmed El-Mahallawy, Nahla Bahgat, Hanaa Mahmoud Alam El-Din, Samah A Farag, Akram Nouh, Inas El-Attar

Affiliations

  1. Clinical Pathology Department, National Cancer Institute, Cairo University.

PMID: 15912152

Abstract

BACKGROUND: It has been recently hypothe-sized that Helicobacter pylori (H. pylori) and Hepatitis C virus (HCV) might be involved in the pathogenesis of malignant non-Hodgkin's lymphoma (NHL). However, most of the studies were carried out on adult patients. On the basis of this observation, we sought to determine the prevalence of these infections in pediatric NHL patients at National Cancer Institute (NCI) and whether there is any clinical or histopathologic picture linked to the presence of these infectious agents.

PATIENTS AND METHODS: The study was performed on 119 pediatric NHL patients, either as new or relapse cases, at the hematology out patient clinic of NCI from January 2002 to July 2003. Thirty apparently healthy children were studied as the control. We searched for H. pylori IgG antibodies using an enzyme immuno-assay (EIA) procedure. HCV was investigated by EIA to detect its antibodies, reverse transcriptase polymerase chain reaction (RT-PCR) for the presence of its RNA and viral sequencing for the determination of the viral genotype.

RESULTS: Antibodies for H. pylori were detected in 51/119 (43.2%) and in none of the control group, p

CONCLUSIONS: We report a high prevalence of HCV and H. pylori infections in paediatric NHL patients at NCI. Concerning the hypothesis of their pathogenetic role in lymphomagenesis, it is still unclear whether these agents have a direct role in malignant transformation in pediatric lymphoma because a typical NHL clinico-histological feature associated with HCV and H. pylori is lacking.

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