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Ashmarin IP, Samonina GE, Lyapina LA, et al. Natural and hybrid ("chimeric") stable regulatory glyproline peptides. Pathophysiology. 2005;11(4):179-185doi: 10.1016/j.pathophys.2004.10.001.
Ashmarin, I. P., Samonina, G. E., Lyapina, L. A., Kamenskii, A. A., Levitskaya, N. G., Grivennikov, I. A., Dolotov, O. V., Andreeva, L. A., & Myasoedov, N. F. (2005). Natural and hybrid ("chimeric") stable regulatory glyproline peptides. Pathophysiology : the official journal of the International Society for Pathophysiology, 11(4), 179-185. https://doi.org/10.1016/j.pathophys.2004.10.001
Ashmarin, I P, et al. "Natural and hybrid ("chimeric") stable regulatory glyproline peptides." Pathophysiology : the official journal of the International Society for Pathophysiology vol. 11,4 (2005): 179-185. doi: https://doi.org/10.1016/j.pathophys.2004.10.001
Ashmarin IP, Samonina GE, Lyapina LA, Kamenskii AA, Levitskaya NG, Grivennikov IA, Dolotov OV, Andreeva LA, Myasoedov NF. Natural and hybrid ("chimeric") stable regulatory glyproline peptides. Pathophysiology. 2005 May;11(4):179-185. doi: 10.1016/j.pathophys.2004.10.001. PMID: 15837162.
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Pathophysiology. 2005 May;11(4):179-185. doi: 10.1016/j.pathophys.2004.10.001.

Natural and hybrid ("chimeric") stable regulatory glyproline peptides.

Pathophysiology : the official journal of the International Society for Pathophysiology

I P Ashmarin, G E Samonina, L A Lyapina, A A Kamenskii, N G Levitskaya, I A Grivennikov, O V Dolotov, L A Andreeva, N F Myasoedov

Affiliations

  1. Chair of Animal and Human Physiology, M.V. Lomonosov Moscow State University, Vorobjevy Gory 1, Building 12, Moscow 119899, Russia.

PMID: 15837162 DOI: 10.1016/j.pathophys.2004.10.001

Abstract

The present concept of relative instability of regulatory peptides (RPs) in organisms must be amended. The recently characterized family of glyprolines and some other prolyl-glycyl-proline (PGP)-containing oligopeptides show the stability quite comparable with those of major pharmacological preparations. The ability of glyprolines to pass gastro-enteric tract barriers opens ways to per-oral administration of this new group of drugs such as semax, selank and their fragments. The most interesting approach is the creation of hybrid ("chimeric") peptide drugs combining the unmodified representatives of various natural RPs that distinctly manifest their inherent physiological activities and cooperate with each other in stabilization of whole peptide in vivo. As the result, the activity of such peptides as semax and selank may have value in a vide variety of pathological processes.

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