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J Am Chem Soc. 2005 May 25;127(20):7284-5. doi: 10.1021/ja051759j.

Catalytic enantioselective thioester aldol reactions that are compatible with protic functional groups.

Journal of the American Chemical Society

Derek Magdziak, Gojko Lalic, Hong Myung Lee, Kevin C Fortner, Allen D Aloise, Matthew D Shair

Affiliations

  1. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

PMID: 15898756 DOI: 10.1021/ja051759j

Abstract

This communication reports highly enantioselective and diastereoselective methyl malonic acid half thioester (MeMAHT) aldol reactions that are compatible with protic functional groups and enolizable aldehydes, affording syn S-phenyl thiopropionates.

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