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Wang B, Bonin M, Micouin L. A straightforward synthesis of ynones by reaction of dimethylalkynylaluminum reagents with acid chlorides. J Org Chem. 2005;70(15):6126-8doi: 10.1021/jo050760y.
Wang, B., Bonin, M., & Micouin, L. (2005). A straightforward synthesis of ynones by reaction of dimethylalkynylaluminum reagents with acid chlorides. The Journal of organic chemistry, 70(15), 6126-8. https://doi.org/10.1021/jo050760y
Wang, Baomin, et al. "A straightforward synthesis of ynones by reaction of dimethylalkynylaluminum reagents with acid chlorides." The Journal of organic chemistry vol. 70,15 (2005): 6126-8. doi: https://doi.org/10.1021/jo050760y
Wang B, Bonin M, Micouin L. A straightforward synthesis of ynones by reaction of dimethylalkynylaluminum reagents with acid chlorides. J Org Chem. 2005 Jul 22;70(15):6126-8. doi: 10.1021/jo050760y. PMID: 16018717.
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J Org Chem. 2005 Jul 22;70(15):6126-8. doi: 10.1021/jo050760y.

A straightforward synthesis of ynones by reaction of dimethylalkynylaluminum reagents with acid chlorides.

The Journal of organic chemistry

Baomin Wang, Martine Bonin, Laurent Micouin

Affiliations

  1. Laboratoire de Chimie Thérapeutique, UMR 8638 associée au CNRS et à l'Université René Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, 4 avenue de l'Observatoire, 75270 Paris Cedex 06, France.

PMID: 16018717 DOI: 10.1021/jo050760y

Abstract

Alkynyldimethylaluminum reagents react with various aromatic and aliphatic acid chlorides in a fast and efficient way. This reaction provides a simple entry to numerous ynones, using readily available, inexpensive, and nontoxic metalating agent, and does not require any transition metal as a catalyst.

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