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Bisset SA, Vlassoff A, McMurtry LW, et al. An evaluation of an oral formulation of moxidectin against selected anthelmintic-resistant and -susceptible strains of nematodes in lambs. N Z Vet J. 1992;40(3):97-100doi: 10.1080/00480169.1992.35708.
Bisset, S. A., Vlassoff, A., McMurtry, L. W., Elliott, D. C., Cobb, R. M., Kieran, P. J., & Wood, I. B. (1992). An evaluation of an oral formulation of moxidectin against selected anthelmintic-resistant and -susceptible strains of nematodes in lambs. New Zealand veterinary journal, 40(3), 97-100. https://doi.org/10.1080/00480169.1992.35708
Bisset, S A, et al. "An evaluation of an oral formulation of moxidectin against selected anthelmintic-resistant and -susceptible strains of nematodes in lambs." New Zealand veterinary journal vol. 40,3 (1992): 97-100. doi: https://doi.org/10.1080/00480169.1992.35708
Bisset SA, Vlassoff A, McMurtry LW, Elliott DC, Cobb RM, Kieran PJ, Wood IB. An evaluation of an oral formulation of moxidectin against selected anthelmintic-resistant and -susceptible strains of nematodes in lambs. N Z Vet J. 1992 Sep;40(3):97-100. doi: 10.1080/00480169.1992.35708. PMID: 16031668.
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N Z Vet J. 1992 Sep;40(3):97-100. doi: 10.1080/00480169.1992.35708.

An evaluation of an oral formulation of moxidectin against selected anthelmintic-resistant and -susceptible strains of nematodes in lambs.

New Zealand veterinary journal

S A Bisset, A Vlassoff, L W McMurtry, D C Elliott, R M Cobb, P J Kieran, I B Wood

Affiliations

  1. Wallaceville Animal Research Centre, MAF Technology, PO Box 40-063, Upper Hutt, New Zealand.

PMID: 16031668 DOI: 10.1080/00480169.1992.35708

Abstract

The efficacy of an oral formulation of the newly developed parasiticide, moxidectin, was tested against benzimidazole-resistant Haemonchus contortus, Trichostrongylus colubriformis, and Nematodirus spathiger, levamisole-resistant Ostertagia circumcincta, and susceptible Cooperia curticei infections in weaned lambs. Thirty-two lambs were experimentally infected with mixed doses of the above strains of nematodes. They were allocated into four treatment groups by stratified randomisation using liveweights and faecal egg counts 28 days later. One group received moxidectin at 0.2 mg/kg liveweight, one group oxfendazole at 4.5 mg/kg liveweight, one group levamisole at 7.5 mg/kg liveweight and the last group remained untreated as the control. Worm burdens in the lambs at slaughter 10 days after oral treatment confirmed the resistance status of the nematode strains used, and showed that moxidectin had a greater than 99.9% efficacy (p<0.01) against all of them. No adverse effects due to treatment with moxidectin were observed in any of the animals.

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