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Horuk R, Goodwin P, O'connor K, et al. Evolutionary change in the insulin receptors of hystricomorph rodents. Nature. 1979;279(5712):439-40doi: 10.1038/279439a0.
Horuk, R., Goodwin, P., O'connor, K., Neville, R. W., Lazarus, N. R., & Stone, D. (1979). Evolutionary change in the insulin receptors of hystricomorph rodents. Nature, 279(5712), 439-40. https://doi.org/10.1038/279439a0
Horuk, R, et al. "Evolutionary change in the insulin receptors of hystricomorph rodents." Nature vol. 279,5712 (1979): 439-40. doi: https://doi.org/10.1038/279439a0
Horuk R, Goodwin P, O'connor K, Neville RW, Lazarus NR, Stone D. Evolutionary change in the insulin receptors of hystricomorph rodents. Nature. 1979 May 31;279(5712):439-40. doi: 10.1038/279439a0. PMID: 16068186.
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Nature. 1979 May 31;279(5712):439-40. doi: 10.1038/279439a0.

Evolutionary change in the insulin receptors of hystricomorph rodents.

Nature

R Horuk, P Goodwin, K O'connor, R W Neville, N R Lazarus, D Stone

PMID: 16068186 DOI: 10.1038/279439a0

Abstract

INSULIN receptors have been thought to have remained unaltered despite evolutionary changes in the hormone(1). Because insulins from hystricomorph rodents are known to be highly substituted compared with other mammalian insulins, we decided to investigate the insulin receptor of some hystricomorphs to determine whether evolutionary change had occurred within the receptor itself. Here we present the first evidence that hystricomorph rodent insulin receptors have undergone evolutionary change.

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