Display options
Cite
Bachmann J, Kleeff J, Bergmann F, et al. Pancreatic metastasis of Merkel cell carcinoma and concomitant insulinoma: case report and literature review. World J Surg Oncol. 2005;3:58doi: 10.1186/1477-7819-3-58.
Bachmann, J., Kleeff, J., Bergmann, F., Shrikhande, S. V., Hartschuh, W., Büchler, M. W., & Friess, H. (2005). Pancreatic metastasis of Merkel cell carcinoma and concomitant insulinoma: case report and literature review. World journal of surgical oncology, 358. https://doi.org/10.1186/1477-7819-3-58
Bachmann, Jeannine, et al. "Pancreatic metastasis of Merkel cell carcinoma and concomitant insulinoma: case report and literature review." World journal of surgical oncology vol. 3 (2005): 58. doi: https://doi.org/10.1186/1477-7819-3-58
Bachmann J, Kleeff J, Bergmann F, Shrikhande SV, Hartschuh W, Büchler MW, Friess H. Pancreatic metastasis of Merkel cell carcinoma and concomitant insulinoma: case report and literature review. World J Surg Oncol. 2005 Sep 01;3:58. doi: 10.1186/1477-7819-3-58. PMID: 16137328; PMCID: PMC1208966.
Copy Download .nbib Format: NLM
Share it on

World J Surg Oncol. 2005 Sep 01;3:58. doi: 10.1186/1477-7819-3-58.

Pancreatic metastasis of Merkel cell carcinoma and concomitant insulinoma: case report and literature review.

World journal of surgical oncology

Jeannine Bachmann, Jorg Kleeff, Frank Bergmann, Shailesh V Shrikhande, Wolfgang Hartschuh, Markus W Büchler, Helmut Friess

Affiliations

  1. Department of General Surgery, University of Heidelberg, Heidelberg, Germany. [email protected]

PMID: 16137328 PMCID: PMC1208966 DOI: 10.1186/1477-7819-3-58

Abstract

BACKGROUND: Merkel cell carcinomas are rare neoplasm of neuroendocrine origin, usually observed in elderly people in areas with abundant sunlight, and predominantly located on the head and neck, extremities, and trunk. In many patients, a local recurrence after resection of the primary tumour and even distant metastases can be found.

CASE PRESENTATION: We report an unusual occurrence of pancreatic metastases from a previously diagnosed Merkel cell carcinoma with the discovery of a concomitant insulinoma. An 82-year old lady suffered from recurrent attacks of hypoglycemia and presented with an abdominal mass, 2 years prior she had an excision done on her eyebrow that was reported as Merkel cell carcinoma. An extended distal pancreatectomy and splenectomy along with resection of the left flexure of the colon for her abdominal mass was carried out. Final histopathology of the mass was a poorly differentiated endocrine carcinoma in the pancreatic tail, in the peripancreatic tissue and in the surrounding soft tissue consistent with metastatic Merkel cell carcinoma in addition to an insulinoma of the pancreatic body.

CONCLUSION: This is the first documented case of a metastatic Merkel cell carcinoma and a concomitant insulinoma, suggesting either a mere coincidence or an unknown neuroendocrine tumor syndrome.

References

  1. Gastrointest Endosc. 2004 Nov;60(5):856-8 - PubMed
  2. Am J Clin Oncol. 2004 Dec;27(6):576-83 - PubMed
  3. Am J Clin Oncol. 2004 Dec;27(6):636-7 - PubMed
  4. Pancreas. 2002 Jan;24(1):103-5 - PubMed
  5. Ann Surg Oncol. 2001 Apr;8(3):204-8 - PubMed
  6. Am J Gastroenterol. 1999 Jul;94(7):1955-7 - PubMed
  7. Cancer. 1999 Jun 15;85(12):2589-95 - PubMed
  8. Laryngoscope. 1992 Mar;102(3):244-9 - PubMed
  9. Virchows Arch. 2004 Jun;444(6):527-35 - PubMed
  10. JOP. 2004 Mar;5(2):92-6 - PubMed
  11. Radiographics. 2002 Mar-Apr;22(2):367-76 - PubMed
  12. Am J Clin Oncol. 2004 Oct;27(5):510-5 - PubMed
  13. J Clin Oncol. 2005 Apr 1;23(10):2300-9 - PubMed
  14. J Surg Oncol. 2005 Jan 1;89(1):1-4 - PubMed
  15. J Cutan Pathol. 2005 Feb;32(2):162-5 - PubMed
  16. Dermatol Surg. 1995 Aug;21(8):669-83 - PubMed
  17. J Am Acad Dermatol. 1993 Aug;29(2 Pt 1):143-56 - PubMed
  18. Otolaryngol Clin North Am. 1993 Apr;26(2):295-309 - PubMed
  19. Am J Surg. 1997 Dec;174(6):688-93 - PubMed
  20. Anticancer Res. 1997 Jan-Feb;17(1B):673-7 - PubMed
  21. AJR Am J Roentgenol. 1996 Sep;167(3):617-20 - PubMed

Publication Types