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J Biosci Bioeng. 2001;92(1):86-8. doi: 10.1263/jbb.92.86.

Preparation of methyl ursodeoxycholate in an interface bioreactor: use of a mixed solvent system to increase the solubilities of substrate and product.

Journal of bioscience and bioengineering

S Oda, T Sugai, H Ohta

Affiliations

  1. Technical Research Laboratory, Kansai Paint Co. Ltd., 4-17-1 Higashi-Yawata, Hiratsuka, Kanagawa 254-8562, Japan. [email protected]

PMID: 16233065 DOI: 10.1263/jbb.92.86

Abstract

A mixed solvent system was used as the reaction solvent of an interface bioreactor for the first time. The solvent, dodecane/2-ethylhexyl acetate (4:6), exhibited excellent efficiency in the preparation of methyl ursodeoxycholate with Eubacterium aerofaciens JCM 7790.

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