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McCully KK, Malucelli E, Iotti S. Increase of free Mg2+ in the skeletal muscle of chronic fatigue syndrome patients. Dyn Med. 2006;5:1doi: 10.1186/1476-5918-5-1.
McCully, K. K., Malucelli, E., & Iotti, S. (2006). Increase of free Mg2+ in the skeletal muscle of chronic fatigue syndrome patients. Dynamic medicine : DM, 51. https://doi.org/10.1186/1476-5918-5-1
McCully, Kevin K, et al. "Increase of free Mg2+ in the skeletal muscle of chronic fatigue syndrome patients." Dynamic medicine : DM vol. 5 (2006): 1. doi: https://doi.org/10.1186/1476-5918-5-1
McCully KK, Malucelli E, Iotti S. Increase of free Mg2+ in the skeletal muscle of chronic fatigue syndrome patients. Dyn Med. 2006 Jan 11;5:1. doi: 10.1186/1476-5918-5-1. PMID: 16405724; PMCID: PMC1360067.
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Dyn Med. 2006 Jan 11;5:1. doi: 10.1186/1476-5918-5-1.

Increase of free Mg2+ in the skeletal muscle of chronic fatigue syndrome patients.

Dynamic medicine : DM

Kevin K McCully, Emil Malucelli, Stefano Iotti

Affiliations

  1. Department of Kinesiology, University of Georgia, Athens, GA 30602, USA. [email protected]

PMID: 16405724 PMCID: PMC1360067 DOI: 10.1186/1476-5918-5-1

Abstract

In a previous study we evaluated muscle blood flow and muscle metabolism in patients diagnosed with chronic fatigue syndrome (CFS). To better understand muscle metabolism in CFS, we re-evaluated our data to calculate free Magnesium levels in skeletal muscle. Magnesium is an essential cofactor in a number of cell processes. A total of 20 CFS patients and 11 controls were evaluated. Phosphorus magnetic resonance spectroscopy from the medial gastrocnemius muscle was used to calculate free Mg2+ from the concentrations and chemical shifts of Pi, PCr, and beta ATP peaks. CFS patients had higher magnesium levels in their muscles relative to controls (0.47 + 0.07 vs 0.36 + 0.06 mM, P < 0.01), although there was no difference in the rate of phosphocreatine recovery in these subjects, as reported earlier. This finding was not associated with abnormal oxidative metabolism as measured by the rate of recovery of phosphocreatine after exercise. In summary, calculation of free Mg2+ levels from previous data showed CFS patients had higher resting free Mg2+ levels compared to sedentary controls.

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