Display options
Cite
Yamaji H, Sakai K, Joho T, et al. Cell cycle analysis of Chinese hamster ovary cells stimulated by phosphatidic acid in serum-free culture. J Biosci Bioeng. 2004;98(6):487-9doi: 10.1016/S1389-1723(05)00317-8.
Yamaji, H., Sakai, K., Joho, T., Izumoto, E., & Fukuda, H. (2004). Cell cycle analysis of Chinese hamster ovary cells stimulated by phosphatidic acid in serum-free culture. Journal of bioscience and bioengineering, 98(6), 487-9. https://doi.org/10.1016/S1389-1723(05)00317-8
Yamaji, Hideki, et al. "Cell cycle analysis of Chinese hamster ovary cells stimulated by phosphatidic acid in serum-free culture." Journal of bioscience and bioengineering vol. 98,6 (2004): 487-9. doi: https://doi.org/10.1016/S1389-1723(05)00317-8
Yamaji H, Sakai K, Joho T, Izumoto E, Fukuda H. Cell cycle analysis of Chinese hamster ovary cells stimulated by phosphatidic acid in serum-free culture. J Biosci Bioeng. 2004;98(6):487-9. doi: 10.1016/S1389-1723(05)00317-8. PMID: 16233741.
Copy Download .nbib Format: NLM
Share it on

J Biosci Bioeng. 2004;98(6):487-9. doi: 10.1016/S1389-1723(05)00317-8.

Cell cycle analysis of Chinese hamster ovary cells stimulated by phosphatidic acid in serum-free culture.

Journal of bioscience and bioengineering

Hideki Yamaji, Kentaro Sakai, Tsukasa Joho, Eiji Izumoto, Hideki Fukuda

Affiliations

  1. Department of Chemical Science and Engineering, Faculty of Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan. [email protected]

PMID: 16233741 DOI: 10.1016/S1389-1723(05)00317-8

Abstract

When recombinant Chinese hamster ovary cells were treated with pertussis toxin or genistein, not only lysophosphatidic acid (LPA) but also phosphatidic acid (PA) failed to stimulate progression through the cell cycle in serum-free culture, suggesting that PA and LPA induce cell growth through the same signal transduction pathway. Cell cycle analysis also indicates that cell growth promoted by PA results in enhanced protein production.

Publication Types