Display options
Share it on

Org Lett. 2005 Oct 27;7(22):4811-4. doi: 10.1021/ol051378a.

A thieno-2H-chromene alpha-amino acid derivative: synthesis and photochromic properties.

Organic letters

Maria-João R P Queiroz, Ana S Abreu, Paula M T Ferreira, M Manuel Oliveira, Roger Dubest, Jean Aubard, André Samat

Affiliations

  1. Departamento de Química, Universidade do Minho, Campus de Gualtar, Braga, Portugal. [email protected]

PMID: 16235895 DOI: 10.1021/ol051378a

Abstract

[structure: see text] A new photochromic thieno-2H-chromene alpha-amino acid derivative was prepared by C-N palladium-catalyzed cross-coupling of a bromothieno-2H-chromene with the aminated aromatic side chain of the methyl ester of a N,N-diprotected amino acid. Its good photochromic properties demonstrated by flash photolysis and continuous irradiation indicate a possible application in ophthalmic lenses. It may also be inserted into peptides to give photoinduced reversible structural changes.

Publication Types