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Siddiqui BS, Begum S, Adil Q, et al. Acetates and benzoates of alkyl catechols and evaluation of their antibacterial activity. Pak J Pharm Sci. 1997;10(2):1-12
Siddiqui, B. S., Begum, S., Adil, Q., Akber, M., Firdous, S., Khan, K. A., Khan, S. A., & Khalid, S. M. (1997). Acetates and benzoates of alkyl catechols and evaluation of their antibacterial activity. Pakistan journal of pharmaceutical sciences, 10(2), 1-12.
Siddiqui, B S, et al. "Acetates and benzoates of alkyl catechols and evaluation of their antibacterial activity." Pakistan journal of pharmaceutical sciences vol. 10,2 (1997): 1-12.
Siddiqui BS, Begum S, Adil Q, Akber M, Firdous S, Khan KA, Khan SA, Khalid SM. Acetates and benzoates of alkyl catechols and evaluation of their antibacterial activity. Pak J Pharm Sci. 1997 Jul;10(2):1-12. PMID: 16414796.
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Pak J Pharm Sci. 1997 Jul;10(2):1-12.

Acetates and benzoates of alkyl catechols and evaluation of their antibacterial activity.

Pakistan journal of pharmaceutical sciences

B S Siddiqui, S Begum, Q Adil, M Akber, S Firdous, K A Khan, S A Khan, S M Khalid

Affiliations

  1. H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.

PMID: 16414796

Abstract

Potential biologically active alkyl catechol esters were prepared and their antibacterial activity was determined against 12 Gram-positive and 16 Gram-negative bacteria. Esterification (acetylation and benzoylation) of mono-, di- and tetra- substituted alkyl catechols afforded the di-acetyl and di-benzoyl derivatives in each case. In the primary screening it was observed that the substitution of hydroxyl group in alkyl catechol with an acyl group generally resulted in a decrease of antibacterial activity. A number of acetyl and benzoyl derivatives inhibited the growth of Salmonella typhi. In case of Gram-positive bacteria only di-O-benzoyl-3,5,6,-tetra-(3-hexyl) catechol (26) showed a significant activity.

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