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Vasto S, Malavolta M, Pawelec G. Age and immunity. Immun Ageing. 2006;3:2doi: 10.1186/1742-4933-3-2.
Vasto, S., Malavolta, M., & Pawelec, G. (2006). Age and immunity. Immunity & ageing : I & A, 32. https://doi.org/10.1186/1742-4933-3-2
Vasto, Sonya, et al. "Age and immunity." Immunity & ageing : I & A vol. 3 (2006): 2. doi: https://doi.org/10.1186/1742-4933-3-2
Vasto S, Malavolta M, Pawelec G. Age and immunity. Immun Ageing. 2006 Feb 24;3:2. doi: 10.1186/1742-4933-3-2. PMID: 16504129; PMCID: PMC1402324.
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Immun Ageing. 2006 Feb 24;3:2. doi: 10.1186/1742-4933-3-2.

Age and immunity.

Immunity & ageing : I & A

Sonya Vasto, Marco Malavolta, Graham Pawelec

Affiliations

  1. Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Italia. [email protected]

PMID: 16504129 PMCID: PMC1402324 DOI: 10.1186/1742-4933-3-2

Abstract

Longitudinal studies are defining progressive alterations to the immune system associated with increased mortality in the very elderly. Many of these changes are exacerbated by or even caused by chronic T cell stimulation by persistent antigen, particularly from Cytomegalovirus. The composition of T cell subsets, their functional integrity and representation in the repertoire are all markedly influenced by age and by CMV. How these findings relate to epidemiological, functional, genetic, genomic and proteomic studies of human T cell immunosenescence was the subject of intense debate at an international conference held just before Christmas 2005 in the Black Forest.

References

  1. Exp Gerontol. 2004 Apr;39(4):607-13 - PubMed
  2. Exp Gerontol. 2006 Jan;41(1):69-77 - PubMed
  3. Ann N Y Acad Sci. 2004 Jun;1019:178-85 - PubMed
  4. Exp Gerontol. 2004 Apr;39(4):577-85 - PubMed
  5. Arthritis Res Ther. 2003;5(6):290-302 - PubMed
  6. Exp Gerontol. 2004 Apr;39(4):637-44 - PubMed
  7. Immunol Rev. 2005 Jun;205:114-29 - PubMed
  8. Prog Neurobiol. 2005 Apr;75(6):367-90 - PubMed
  9. Science. 2005 Jan 14;307(5707):208-9; author reply 208-9 - PubMed
  10. Mech Ageing Dev. 2005 Aug;126(8):855-65 - PubMed
  11. JAMA. 2004 Nov 17;292(19):2339-40 - PubMed
  12. Hum Immunol. 2005 Mar;66(3):222-30 - PubMed
  13. Cell Signal. 2006 Jul;18(7):1017-30 - PubMed
  14. J Immunol. 2005 Sep 15;175(6):4112-8 - PubMed
  15. Immunol Rev. 2005 Jun;205:257-68 - PubMed
  16. Trends Immunol. 2004 Aug;25(8):406-10 - PubMed
  17. Cell Mol Life Sci. 2005 Jan;62(1):77-86 - PubMed
  18. Exp Gerontol. 2004 Aug;39(8):1233-43 - PubMed
  19. Exp Gerontol. 2004 Apr;39(4):499-505 - PubMed
  20. Eur J Immunol. 2005 Oct;35(10):2876-85 - PubMed
  21. J Clin Immunol. 2003 Jul;23(4):247-57 - PubMed
  22. J Gerontol A Biol Sci Med Sci. 2005 May;60(5):556-65 - PubMed
  23. Pharmacol Res. 2005 Jul;52(1):93-9 - PubMed
  24. J Immunol. 2004 Dec 15;173(12):7481-9 - PubMed
  25. Ann N Y Acad Sci. 2004 Dec;1030:125-33 - PubMed

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