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Williams DN, Ehrman SH, Pulliam Holoman TR. Evaluation of the microbial growth response to inorganic nanoparticles. J Nanobiotechnology. 2006;4:3doi: 10.1186/1477-3155-4-3.
Williams, D. N., Ehrman, S. H., & Pulliam Holoman, T. R. (2006). Evaluation of the microbial growth response to inorganic nanoparticles. Journal of nanobiotechnology, 43. https://doi.org/10.1186/1477-3155-4-3
Williams, Darryl N, et al. "Evaluation of the microbial growth response to inorganic nanoparticles." Journal of nanobiotechnology vol. 4 (2006): 3. doi: https://doi.org/10.1186/1477-3155-4-3
Williams DN, Ehrman SH, Pulliam Holoman TR. Evaluation of the microbial growth response to inorganic nanoparticles. J Nanobiotechnology. 2006 Feb 28;4:3. doi: 10.1186/1477-3155-4-3. PMID: 16507102; PMCID: PMC1444930.
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J Nanobiotechnology. 2006 Feb 28;4:3. doi: 10.1186/1477-3155-4-3.

Evaluation of the microbial growth response to inorganic nanoparticles.

Journal of nanobiotechnology

Darryl N Williams, Sheryl H Ehrman, Tracey R Pulliam Holoman

Affiliations

  1. Department of Chemical and Biomolecular Engineering, University of Maryland, 2113 Building 090, College Park, MD 20742, USA. [email protected]

PMID: 16507102 PMCID: PMC1444930 DOI: 10.1186/1477-3155-4-3

Abstract

In order to enhance the utilization of inorganic nanoparticles in biological systems, it is important to develop a fundamental understanding of the influence they have on cellular health and function. Experiments were conducted to test silica, silica/iron oxide, and gold nanoparticles for their effects on the growth and activity of Escherichia coli (E. coli). Transmission electron microscopy (TEM) and dynamic light scattering (DLS) were used to characterize the morphology and quantify size distribution of the nanoparticles, respectively. TEM was also used to verify the interactions between composite iron oxide nanoparticles and E. coli. The results from DLS indicated that the inorganic nanoparticles formed small aggregates in the growth media. Growth studies measured the influence of the nanoparticles on cell proliferation at various concentrations, showing that the growth of E. coli in media containing the nanoparticles indicated no overt signs of toxicity.

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