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van Zuilen AD, van der Tweel I, Blankestijn PJ, et al. Multifactorial approach and superior treatment efficacy in renal patients with the aid of nurse practitioners. Design of The MASTERPLAN Study [ISRCTN73187232]. Trials. 2006;7:8doi: 10.1186/1745-6215-7-8.
van Zuilen, A. D., van der Tweel, I., Blankestijn, P. J., Bots, M. L., van Buren, M., ten Dam, M. A., Kaasjager, K. A., van de Ven, P. J., Vervoort, G., Vleming, L. J., Ligtenberg, G., Wetzels, J. F. (2006). Multifactorial approach and superior treatment efficacy in renal patients with the aid of nurse practitioners. Design of The MASTERPLAN Study [ISRCTN73187232]. Trials, 78. https://doi.org/10.1186/1745-6215-7-8
van Zuilen, Arjan D, et al. "Multifactorial approach and superior treatment efficacy in renal patients with the aid of nurse practitioners. Design of The MASTERPLAN Study [ISRCTN73187232]." Trials vol. 7 (2006): 8. doi: https://doi.org/10.1186/1745-6215-7-8
van Zuilen AD, van der Tweel I, Blankestijn PJ, Bots ML, van Buren M, ten Dam MA, Kaasjager KA, van de Ven PJ, Vervoort G, Vleming LJ, Ligtenberg G, Wetzels JF. Multifactorial approach and superior treatment efficacy in renal patients with the aid of nurse practitioners. Design of The MASTERPLAN Study [ISRCTN73187232]. Trials. 2006 Mar 30;7:8. doi: 10.1186/1745-6215-7-8. PMID: 16573836; PMCID: PMC1459200.
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Trials. 2006 Mar 30;7:8. doi: 10.1186/1745-6215-7-8.

Multifactorial approach and superior treatment efficacy in renal patients with the aid of nurse practitioners. Design of The MASTERPLAN Study [ISRCTN73187232].

Trials

Arjan D van Zuilen, Ingeborgh van der Tweel, Peter J Blankestijn, Michiel L Bots, Marjolijn van Buren, Marc A G J ten Dam, Karin A H Kaasjager, Peter J G van de Ven, Gerald Vervoort, Louis-Jean Vleming, Gerry Ligtenberg, Jack F M Wetzels,

Affiliations

  1. Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands. [email protected]

PMID: 16573836 PMCID: PMC1459200 DOI: 10.1186/1745-6215-7-8

Abstract

BACKGROUND: Patients with chronic kidney disease (CKD) are at a greatly increased risk of developing cardiovascular disease. Recently developed guidelines address multiple risk factors and life-style interventions. However, in current practice few patients reach their targets.A multifactorial approach with the aid of nurse practitioners was effective in achieving treatment goals and reducing vascular events in patients with diabetes mellitus and in patients with heart failure. We propose that this also holds for the CKD population.

DESIGN: MASTERPLAN is a multicenter randomized controlled clinical trial designed to evaluate whether a multifactorial approach with the aid of nurse-practicioners reduces cardiovascular risk in patients with CKD. Approximately 800 patients with a creatinine clearance (estimated by Cockcroft-Gault) between 20 to 70 ml/min, will be included. To all patients the same set of guidelines will be applied and specific cardioprotective medication will be prescribed. In the intervention group the nurse practitioner will provide lifestyle advice and actively address treatment goals. Follow-up will be five years. Primary endpoint is the composite of myocardial infarction, stroke and cardiovascular mortality. Secondary endpoints are cardiovascular morbidity, overall mortality, decline of renal function, change in markers of vascular damage and change in quality of life. Enrollment has started in April 2004 and the study is on track with 700 patients included on October 15th, 2005. This article describes the design of the MASTERPLAN study.

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