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Gregorini G, Laloue M. Biological Effects of Cytokinin Antagonists 7-(Pentylamino) and 7-(Benzylamino)-3-Methylpyrazolo(4,3-d)Pyrimidines on Suspension-cultured Tobacco Cells. Plant Physiol. 1980;65(2):363-7doi: 10.1104/pp.65.2.363.
Gregorini, G., & Laloue, M. (1980). Biological Effects of Cytokinin Antagonists 7-(Pentylamino) and 7-(Benzylamino)-3-Methylpyrazolo(4,3-d)Pyrimidines on Suspension-cultured Tobacco Cells. Plant physiology, 65(2), 363-7. https://doi.org/10.1104/pp.65.2.363
Gregorini, G, and Laloue, M. "Biological Effects of Cytokinin Antagonists 7-(Pentylamino) and 7-(Benzylamino)-3-Methylpyrazolo(4,3-d)Pyrimidines on Suspension-cultured Tobacco Cells." Plant physiology vol. 65,2 (1980): 363-7. doi: https://doi.org/10.1104/pp.65.2.363
Gregorini G, Laloue M. Biological Effects of Cytokinin Antagonists 7-(Pentylamino) and 7-(Benzylamino)-3-Methylpyrazolo(4,3-d)Pyrimidines on Suspension-cultured Tobacco Cells. Plant Physiol. 1980 Feb;65(2):363-7. doi: 10.1104/pp.65.2.363. PMID: 16661191; PMCID: PMC440328.
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Plant Physiol. 1980 Feb;65(2):363-7. doi: 10.1104/pp.65.2.363.

Biological Effects of Cytokinin Antagonists 7-(Pentylamino) and 7-(Benzylamino)-3-Methylpyrazolo(4,3-d)Pyrimidines on Suspension-cultured Tobacco Cells.

Plant physiology

G Gregorini, M Laloue

Affiliations

  1. Centre National de la Recherche Scientifique, Laboratoire G.P.D.P./P.C., 91190 Gif-sur-Yvette, France.

PMID: 16661191 PMCID: PMC440328 DOI: 10.1104/pp.65.2.363

Abstract

We have studied the biological effects of two structural analogs of cytokinins, 3-methyl-7-(pentylamino)pyrazolo(4,3-d)pyrimidine and 3-methyl-7-(benzylamino)pyrazolo(4,3-d)pyrimidine, on tobacco cell suspension cultures. These two cytokinin analogs are highly inhibitory to cytokinin-autonomous and cytokinin-requiring tobacco cells. The growth inhibitory effect is markedly antagonized by benzyladenine, but not by adenine. Cell suspensions of tobacco cells of a cytokinin-autonomous strain become cytokinin-dependent in the presence of 0.1 micromolar 3-methyl-7-(benzylamino)pyrazolo(4,3-d)pyrimidine. It is also demonstrated that growth inhibition of cell suspension cultures is accompanied by cell death and that only dividing cells are sensitive to this cytotoxic effect.

References

  1. J Biol Chem. 1975 Sep 25;250(18):7343-51 - PubMed
  2. Proc Natl Acad Sci U S A. 1971 Oct;68(10):2608-10 - PubMed

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