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Prout DL, Silverman RW, Chatziioannou A. Readout of the Optical PET (OPET) Detector. IEEE Trans Nucl Sci. 2005;52(1):28-32doi: 10.1109/TNS.2004.843151.
Prout, D. L., Silverman, R. W., & Chatziioannou, A. (2005). Readout of the Optical PET (OPET) Detector. IEEE transactions on nuclear science, 52(1), 28-32. https://doi.org/10.1109/TNS.2004.843151
Prout, D L, et al. "Readout of the Optical PET (OPET) Detector." IEEE transactions on nuclear science vol. 52,1 (2005): 28-32. doi: https://doi.org/10.1109/TNS.2004.843151
Prout DL, Silverman RW, Chatziioannou A. Readout of the Optical PET (OPET) Detector. IEEE Trans Nucl Sci. 2005 Feb;52(1):28-32. doi: 10.1109/TNS.2004.843151. PMID: 16429600; PMCID: PMC1317092.
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IEEE Trans Nucl Sci. 2005 Feb;52(1):28-32. doi: 10.1109/TNS.2004.843151.

Readout of the Optical PET (OPET) Detector.

IEEE transactions on nuclear science

D L Prout, R W Silverman, A Chatziioannou

Affiliations

  1. The authors are with the Crump Institute for Molecular Imaging at the David Geffen School of Medicine, University of California, Los Angeles, CA 90095 USA (e-mail: [email protected] ; [email protected] ; [email protected] ).

PMID: 16429600 PMCID: PMC1317092 DOI: 10.1109/TNS.2004.843151

Abstract

The design of an imaging system capable of detecting both high-energy γ-rays and optical wavelength photons is underway at the Crump Institute for Molecular Imaging. This system will noninvasively image small animal models in vivo for the presence of positron emission tomographic (PET) and optical signals. The detector will consist of modules of multichannel photomultiplier tubes (MC-PMT) coupled to arrays of scintillator crystals. The MC-PMT will detect both the photons produced due to bioluminescence and the photons generated by the interaction of γ-rays within the crystals. The long wavelength photons produced through bioluminescence are only slightly attenuated by these crystals and are detected directly at the photocathode of the MC-PMT, resulting in signals of small (5-10 mV) short (~15 ns) pulses. In contrast, annihilation (511 keV) γ-rays interacting in the scintillator crystal send large bursts of photons to the PMT, and result in pulses that can be as large as 500 mV and > 200 ns duration. The processing of pulses with such different characteristics in a single circuit requires significant alteration of the standard pulse processing circuitry used in PET scanners. In this paper, we discuss the requirements of such a circuit and show the results of implementation of one design using single and multiple channel PMTs.

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