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Prout DL, Silverman RW, Chatziioannou A. Detector Concept for OPET-A Combined PET and Optical Imaging System. IEEE Trans Nucl Sci. 2004;51(3):752-756doi: 10.1109/TNS.2004.829736.
Prout, D. L., Silverman, R. W., & Chatziioannou, A. (2004). Detector Concept for OPET-A Combined PET and Optical Imaging System. IEEE transactions on nuclear science, 51(3), 752-756. https://doi.org/10.1109/TNS.2004.829736
Prout, D L, et al. "Detector Concept for OPET-A Combined PET and Optical Imaging System." IEEE transactions on nuclear science vol. 51,3 (2004): 752-756. doi: https://doi.org/10.1109/TNS.2004.829736
Prout DL, Silverman RW, Chatziioannou A. Detector Concept for OPET-A Combined PET and Optical Imaging System. IEEE Trans Nucl Sci. 2004 Jun;51(3):752-756. doi: 10.1109/TNS.2004.829736. PMID: 16429601; PMCID: PMC1317093.
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IEEE Trans Nucl Sci. 2004 Jun;51(3):752-756. doi: 10.1109/TNS.2004.829736.

Detector Concept for OPET-A Combined PET and Optical Imaging System.

IEEE transactions on nuclear science

D L Prout, R W Silverman, A Chatziioannou

Affiliations

  1. The authors are with the Crump Institute for Molecular Imaging at the Geffen School of Medicine, University of California at Los Angeles (UCLA), Los Angeles, CA 90095 USA (e-mail: [email protected] ; [email protected] ; [email protected] ).

PMID: 16429601 PMCID: PMC1317093 DOI: 10.1109/TNS.2004.829736

Abstract

The design of an imaging system capable of detecting both high-energy γ-rays and optical wavelength photons is underway at the UCLA Crump Institute for Molecular Imaging. This system, which we call optical PET (OPET), will be capable of non-invasively and repeatedly imaging small animal models in vivo for the presence of PET and optical signals. In this study, we describe the physical principles behind the operation of the OPET imaging system and discuss the design concept for one of the detector modules. Additionally, we demonstrate the operation of an initial prototype detector module for simultaneous detection and imaging of annihilation radiation and single optical photons emanating from separate sources. These results indicate that the construction of an imaging system based on this detector technology is feasible.

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